Kalciumtillskott och sjukliga förändringar i hjärnan

[King Grub]

Recent studies have implicated Ca supplements in vascular risk elevation, and therefore these supplements may also be associated with the occurrence of brain lesions (or hyperintensities) in older adults. These lesions represent damage to brain tissue that is caused by ischaemia. In the present cross-sectional clinical observational study, the association between Ca-containing dietary supplement use and lesion volumes was investigated in a sample of 227 older adults (60 years and above). Food and supplemental Ca intakes were assessed with the Block 1998 FFQ; participants with supplemental Ca intake above zero were categorised as supplement users. Lesion volumes were determined from cranial MRI (1·5 tesla) scans using a semi-automated technique; volumes were log-transformed because they were non-normal. ANCOVA models revealed that supplement users had greater lesion volumes than non-users, even after controlling for food Ca intake, age, sex, race, years of education, energy intake, depression and hypertension (Ca supplement use: β = 0·34, se 0·10, F 1,217= 10·98, P= 0·0011). The influence of supplemental Ca use on lesion volume was of a magnitude similar to that of the influence of hypertension, a well-established risk factor for lesions. Among the supplement users, the amount of supplemental Ca was not associated with lesion volume (β = − 0·000035, se 0·00 015, F 1,139= 0·06, P= 0·81). The present study demonstrates that the use of Ca-containing dietary supplements, even low-dose supplements, by older adults may be associated with greater lesion volumes. Evaluation of randomised controlled trials is warranted to determine whether this relationship is a causal one.

Br J Nutr. 2014 Apr 30:1-8. Elevated brain lesion volumes in older adults who use calcium supplements: a cross-sectional clinical observational study.

http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=9251967

[Alltidxx]

Som vi väntar på att HMB ska säljas utan att vara bundet till kalcium...

[Sheogorath]

Till rimliga priser. :)

[ChrillyMcFrill]

Hur mycket kalcium är det i en 1000mg kalciumbundet HMB? Blir lite orolig att dricka 1L mjölk om dagen nu... Undviker ju gärna stora överdoseringar av vissa mikronutrienter.

Fast samtidigt så borde väl man höja RDI för kalcium när man tränar... Hur mycket i så fall? Borde väl vara så då Kalcium används som "transmittor(?)" i muskelceller? Mer aktivitet -> större behov, right? :P

[maqan]

1 liter standardmjölk innehåller 1200 mg kalcium, vilket redan är ganska mycket.

[exevision]

Angående detta så funderar man hur mycket av kalciumet från HMB som kroppen tar upp. Är det ett lättillgängligt kalcium eller inte?

[Kischen]

Evaluation of randomised controlled trials is warranted to determine whether this relationship is a CAUSAL ONE