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Visa fullständig version : Negativ påverkan på blodfetter av paleokost


King Grub
2014-04-28, 07:13
The Paleolithic (Paleo) diet is one modeled after the perceived food consumption of early human ancestors of the Paleolithic Era, consisting of mainly meat, fish, fruit, vegetables, eggs, and nuts. The purpose of this study was to examine the effects of a Paleo diet on blood lipids, including high-density lipoprotein (HDL), low-density lipoprotein (LDL), non-HDL cholesterol, triglycerides (TG), total cholesterol (TC), and the ratio between TC and HDL (TC/HDL) in a healthy population. Healthy subjects of both genders (24 males, 20 females) were asked to eat an ad libitum Paleo diet for 10 weeks. Prior to the intervention, body weight, body fat percentage (BF%), maximal oxygen consumption (VO2max), TC, TG, HDL, and LDL were measured. These measurements were repeated following 10 weeks of a Paleo diet. As a whole, there was a significant increase in non-HDL (107.1±6.0 mg/dL to 120.2±6.5 mg/dL; P<0.01), LDL (93.1±5.4 mg/dL to 105.6±6.1 mg/dL; P<0.01), TC/HDL (3.0±0.2 to 3.3±0.2; P<0.05), and TC (168.8±5.4 mg/dL to 178.9±6.6 mg/dL; P<0.05) in healthy subjects following a Paleo diet. When stratified into groups based on initial blood lipid levels, deleterious changes were found in those with optimal HDL (82.1±3.2 mg/dL to 68.6±4.8 mg/dL; P<0.05), non-HDL (86.6±3.9 mg/dL to 101.4±4.8 mg/dL; P<0.01), TC (157.2±0.7 to 168.2±0.9 mg/dL; P<0.05), TC/HDL (2.5±0.1 to 2.7±0.1; P<0.05), and LDL (69.1±3.1 mg/dL to 83.5±4.1 mg/dL; P<0.01), whereas those within sub-optimal stratifications showed no significant changes. Subjects also decreased body weight (80.7±2.6 kg to 77.5±2.4 kg; P<0.001) and BF% (24.3±1.2% to 20.7±1.2%; P < 0.05). Our results demonstrate that an ad libitum unrestricted Paleo diet intervention is associated with deleterious changes to blood lipids in healthy subjects, despite concurrent improvements in body composition and cardiorespiratory fitness. Future research should focus on determining recommendations that embrace the positive aspects of the Paleo diet, while minimizing any deleterious impact on blood lipids in a healthy population.

International Journal of Exercise Science 7(2) : 128-139, 2014.

http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=1576&context=ijes

stevebc
2014-04-30, 22:18
Från Wikipedia:

LDL subtype patterns[edit]
LDL particles vary in size and density, and studies have shown that a pattern that has more small dense LDL particles, called Pattern B, equates to a higher risk factor for coronary heart disease (CHD) than does a pattern with more of the larger and less-dense LDL particles (Pattern A). This is thought to be because the smaller particles are more easily able to penetrate the endothelium. Pattern I, for intermediate, indicates that most LDL particles are very close in size to the normal gaps in the endothelium (26 nm). According to one study, sizes 19.0–20.5 nm were designated as pattern B and LDL sizes 20.6–22 nm were designated as pattern A.[7]

Some in the medical community have suggested the correspondence between Pattern B and CHD is stronger than the correspondence between the LDL number measured in the standard lipid profile test. Tests to measure these LDL subtype patterns have been more expensive and not widely available, so the common lipid profile test is used more often.[8]

There has also been noted a correspondence between higher triglyceride levels and higher levels of smaller, denser LDL particles and alternately lower triglyceride levels and higher levels of the larger, less dense LDL.[9][10]

With continued research, decreasing cost, greater availability and wider acceptance of other lipoprotein subclass analysis assay methods, including NMR spectroscopy,[11] research studies have continued to show a stronger correlation between human clinically obvious cardiovascular events and quantitatively measured particle concentrations.[citation needed]

Det hade varit intressant att se vilken subtyp av LDL som steg. De större eller de mindre LDL-fraktionerna? Särskilt då mättat fett är känt för att öka koncentrationen av LDL av den större storleken, dvs, förbättra blodfetterna.

stevebc
2014-04-30, 22:39
Dietary Intervention
A Paleolithic diet, as first described by
Eaton and Konner, was implemented for all
study participants (11). Subjects were
advised to increase their consumption of
lean meat, fish, eggs, nuts, fruit, and
vegetables and were instructed to strictly
avoid all grains, dairy products, and
legumes. All modern, processed foods
including any form of processed sugar, soft
drinks, and coffees were also excluded from
the diets of the subjects. No specific
macronutrient recommendations were
made, as the study design wanted to closely
mimic a real world model that would
incorporate food choices made by the
average consumer. Intake of specific
proportion of food categories (e.g. animal
vs. plant foods) was also not given.Från fullängdaren som länkas till ovan.

Det är ju ganska fritt fram att byta ut havregrynsgröten mot Kentucky Fried, om man väljer att bortse från rekommendationerna (ingen processad mat). Svårt för oss att veta vad tusan de egentligen konsumerade. Kalcium i mejeriprodukter och fiber i fullkornsprodukter och baljväxter skulle säkert ha gynnat blodfetterna, och just matvaror som dessa är ju tyvärr "förbjudna" i paleodieten.