King Grub
2014-03-24, 10:36
BACKGROUND:
Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke®, Pepsi®, extra.
OBJECTIVES:
A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated.
METHODS:
Fifteen adult female Wistar rats weighing between 180-200 g were divided into 3 groups; designated as groups A, B and C, and each group consisted of five rats. Group A was the Control group and received distilled water, while groups B and C were the experimental groups. Group B was administered 50 ml of regular soda (RS), and group C was administered 50 ml of diet soda (DS) each per day for 21 days, and the rats were sacrificed on Day 22, and their cerebellums excised and preserved.
RESULTS:
Histological result of the sections of the cerebellum showed shrunken and degenerated Purkinje cells with hypertrophied dendrites, especially in the DS group, which was less in the RS group compared to the control group.
In this study, the Diet soda (DS) group revealed shrunken and degenerated Purkinje cells with hypertrophied dendrites. The Purkinje cells are the only cerebellar efferent neurons12. These alterations in the shape of the Purkinje cells may lead to inadequate signals from the cerebellum to higher centres, a possible non motor coordination function.
Lutsey et al. reported that consuming just a can of diet soda increases one's risk of developing metabolic syndrome. Abeer reported aspartame resulted in the loss of the pyriform shape of Purkinje cells, condensed nuclei with affected processes, vacuolations in the granular and molecular layers, with gliosis and cell death which showed incomplete restoration of the normal structure of the cerebellar cortex upon stoppage. The observed vacuolation and neuronal loss in the cortical layers of the RS group may adversely affect cerebellar function.
CONCLUSION:
This study shows that DS may have adverse effect on the histology of the cerebellum of female albino wistar rats; hence its consumption should be in minimal quantity.
Afr Health Sci. 2013 Sep;13(3):541-5. A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824455/
Carbonated drinks are widely consumed because of their taste and their ability to refresh and quench thirst. These carbonated drinks also exist in the form of diet drinks, for example Diet Coke®, Pepsi®, extra.
OBJECTIVES:
A comparative effect of the diet and regular soda carbonated drinks on the histology of the cerebellum of female albino Wistar rats was investigated.
METHODS:
Fifteen adult female Wistar rats weighing between 180-200 g were divided into 3 groups; designated as groups A, B and C, and each group consisted of five rats. Group A was the Control group and received distilled water, while groups B and C were the experimental groups. Group B was administered 50 ml of regular soda (RS), and group C was administered 50 ml of diet soda (DS) each per day for 21 days, and the rats were sacrificed on Day 22, and their cerebellums excised and preserved.
RESULTS:
Histological result of the sections of the cerebellum showed shrunken and degenerated Purkinje cells with hypertrophied dendrites, especially in the DS group, which was less in the RS group compared to the control group.
In this study, the Diet soda (DS) group revealed shrunken and degenerated Purkinje cells with hypertrophied dendrites. The Purkinje cells are the only cerebellar efferent neurons12. These alterations in the shape of the Purkinje cells may lead to inadequate signals from the cerebellum to higher centres, a possible non motor coordination function.
Lutsey et al. reported that consuming just a can of diet soda increases one's risk of developing metabolic syndrome. Abeer reported aspartame resulted in the loss of the pyriform shape of Purkinje cells, condensed nuclei with affected processes, vacuolations in the granular and molecular layers, with gliosis and cell death which showed incomplete restoration of the normal structure of the cerebellar cortex upon stoppage. The observed vacuolation and neuronal loss in the cortical layers of the RS group may adversely affect cerebellar function.
CONCLUSION:
This study shows that DS may have adverse effect on the histology of the cerebellum of female albino wistar rats; hence its consumption should be in minimal quantity.
Afr Health Sci. 2013 Sep;13(3):541-5. A comparative study of the effect of diet and soda carbonated drinks on the histology of the cerebellum of adult female albino Wistar rats.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824455/