Koffein och insulin

[Cartwright]

Jag vet att koffein frisätter fettsyror i blodet, och därmed ökar insulinet. Jag vet också att jag har läst att koffeinet (därför?) försämrar insulinkänsligheten. Å andra sidan: http://www.annals.org/cgi/content/abstract/140/1/1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=caffeine&searchid=1079162143838_1252&stored_search=&FIRSTINDEX=0&journalcode=annintmed

Hur hänger detta ihop egentligen?

[LunaSpice]

Här är flera studier som bekräftar det du skriver. Varför det är så är fortfarande oklart.

Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women.

Tuomilehto J, Hu G, Bidel S, Lindstrom J, Jousilahti P.

JAMA. 2004 Mar 10;291(10):1213-9.

CONTEXT: Only a few studies of coffee consumption and diabetes mellitus (DM) have been reported, even though coffee is the most consumed beverage in the world. OBJECTIVE: To determine the relationship between coffee consumption and the incidence of type 2 DM among Finnish individuals, who have the highest coffee consumption in the world. DESIGN, SETTING, AND PARTICIPANTS: A prospective study from combined surveys conducted in 1982, 1987, and 1992 of 6974 Finnish men and 7655 women aged 35 to 64 years without history of stroke, coronary heart disease, or DM at baseline, with 175 682 person-years of follow-up. Coffee consumption and other study parameters were determined at baseline using standardized measurements. MAIN OUTCOME MEASURES: Hazard ratios (HRs) for the incidence of type 2 DM were estimated for different levels of daily coffee consumption. RESULTS: During a mean follow-up of 12 years, there were 381 incident cases of type 2 DM. After adjustment for confounding factors (age, study year, body mass index, systolic blood pressure, education, occupational, commuting and leisure-time physical activity, alcohol and tea consumption, and smoking), the HRs of DM associated with the amount of coffee consumed daily (0-2, 3-4, 5-6, 7-9, > or =10 cups) were 1.00, 0.71 (95% confidence interval [CI], 0.48-1.05), 0.39 (95% CI, 0.25-0.60), 0.39 (95% CI, 0.20-0.74), and 0.21 (95% CI, 0.06-0.69) (P for trend<.001) in women, and 1.00, 0.73 (95% CI, 0.47-1.13), 0.70 (95% CI, 0.45-1.05), 0.67 (95% CI, 0.40-1.12), and 0.45 (95% CI, 0.25-0.81) (P for trend =.12) in men, respectively. In both sexes combined, the multivariate-adjusted inverse association was significant (P for trend <.001) and persisted when stratified by younger and older than 50 years; smokers and never smokers; healthy weight, overweight, and obese participants; alcohol drinker and nondrinker; and participants drinking filtered and nonfiltered coffee. CONCLUSION: Coffee drinking has a graded inverse association with the risk of type 2 DM; however, the reasons for this risk reduction associated with coffee remain unclear.

Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study.

Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson S.

J Intern Med. 2004 Jan;255(1):89-95.

OBJECTIVES: To examine the long-term incidence of diabetes in relation to coffee consumption in Swedish women. DESIGN: Prospective longitudinal cohort study. SETTING: City of Goteborg, Sweden. SUBJECTS: A random population sample of 1361 women, aged 39-65 years, without prior diabetes or cardiovascular disease took part in a screening study in 1979-1981 with questionnaires, physical examination and blood sampling. MAIN OUTCOME MEASURES: The development of diabetes until 1999 was identified by questionnaires in a second screening and the Swedish hospital discharge register. RESULTS: Altogether, there were 74 new cases of diabetes. The risk of developing diabetes was 475 per 100 000 person-years in women who consumed two cups of coffee or less per day, 271 in women who consumed three to four cups per day, 202 with a consumption of five to six cups per day, and 267 in drinkers of seven cups or more per day. Associated hazard ratios, after adjustment for age, smoking, low physical activity, education and body mass index were 0.55 (0.32-0.95), 0.39 (0.20-0.77) and 0.48 (0.22-1.06) for daily consumption of three to four, five to six and seven cups or more, respectively, with a consumption of less than two per day as reference. Additional adjustment for serum cholesterol and triglycerides attenuated the relation between coffee and diabetes slightly, indicating a possible mediating effect on the effect of coffee by serum lipids. CONCLUSIONS: The findings of the present study support the hypothesis that coffee consumption protects from the development of diabetes in women.

Här är en studie som tar upp insulinkänslighet och koffein.

Caffeine can decrease insulin sensitivity in humans.

Diabetes Care. 2002 Feb;25(2):364-9.

Keijzers GB, De Galan BE, Tack CJ, Smits P.

OBJECTIVE: Caffeine is a central stimulant that increases the release of catecholamines. As a component of popular beverages, caffeine is widely used around the world. Its pharmacological effects are predominantly due to adenosine receptor antagonism and include release of catecholamines. We hypothesized that caffeine reduces insulin sensitivity, either due to catecholamines and/or as a result of blocking adenosine-mediated stimulation of peripheral glucose uptake. RESEARCH DESIGN AND METHODS: Hyperinsulinemic-euglycemic glucose clamps were used to assess insulin sensitivity. Caffeine or placebo was administered intravenously to 12 healthy volunteers in a randomized, double-blind, crossover design. Measurements included plasma levels of insulin, catecholamines, free fatty acids (FFAs), and hemodynamic parameters. Insulin sensitivity was calculated as whole-body glucose uptake corrected for the insulin concentration. In a second study, the adenosine reuptake inhibitor dipyridamole was tested using an identical protocol in 10 healthy subjects. RESULTS: Caffeine decreased insulin sensitivity by 15% (P < 0.05 vs. placebo). After caffeine administration, plasma FFAs increased (P < 0.05) and remained higher than during placebo. Plasma epinephrine increased fivefold (P < 0.0005), and smaller increases were recorded in plasma norepinephrine (P < 0.02) and blood pressure (P < 0.001). Dipyridamole did not alter insulin sensitivity and only increased plasma norepinephrine (P < 0.01). CONCLUSIONS: Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels. Because dipyridamole did not affect glucose uptake, peripheral adenosine receptor antagonism does not appear to contribute to this effect.

Detta kanske kan vara intressant också:

Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise.

Diabetes. 2002 Mar;51(3):583-90.

Thong FS, Derave W, Kiens B, Graham TE, Urso B, Wojtaszewski JF, Hansen BF, Richter EA.


Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test.

Can J Physiol Pharmacol. 2001 Jul;79(7):559-65.

Graham TE, Sathasivam P, Rowland M, Marko N, Greer F, Battram D.


Kontentan, forskare vet inte varför nya studier helt plötsligt tyder på att koffein skulle kunna ha motsatt verkan mot vad man tidigare trott.

[Cartwright]

Tack för infon! Det hela är ju en smula förvirrande...

[LunaSpice]

Originally posted by Cartwright
Tack för infon! Det hela är ju en smula förvirrande...

Och det tycker även forskarna. :)

[Cartwright]

Aha! Jag har länge misstänkt att kaffe är boten för alla sjukdommar. :)

http://www.aftonbladet.se/vss/foraldrar/story/0,2789,449621,00.html

[MunsöHustla]

Originally posted by Cartwright
Jag vet att koffein frisätter fettsyror i blodet, och därmed ökar insulinet. Jag vet också att jag har läst att koffeinet (därför?) försämrar insulinkänsligheten. Å andra sidan: http://www.annals.org/cgi/content/abstract/140/1/1?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=caffeine&searchid=1079162143838_1252&stored_search=&FIRSTINDEX=0&journalcode=annintmed

Hur hänger detta ihop egentligen?

Det är nu jag börjar undra varför det rekommenderas att ta koffein/dricka kaffe innan morgonpromenaden, eftersträvar man inte så låga insulinnivåer som möjligt då?

[King Grub]

Originally posted by MunsöHustla


Det är nu jag börjar undra varför det rekommenderas att ta koffein/dricka kaffe innan morgonpromenaden, eftersträvar man inte så låga insulinnivåer som möjligt då?

Koffeinet har en termogen effekt mellan runt 10 till 20 procent, och ökar alltså energiförbrukningen. 300 mg koffein ökade energiförbrukningen under 90 minuter med 175 kj hos tränade individer, enligt studier.

Poelhmann EJ et.al: Influence of caffeine on the resting metabolic rate of exercise-trained and inactive subjects. Med Sci Sports Exercise 1985; 17: 689-94

[MunsöHustla]

Originally posted by King Grub


Koffeinet har en termogen effekt mellan runt 10 till 20 procent, och ökar alltså energiförbrukningen. 300 mg koffein ökade energiförbrukningen under 90 minuter med 175 kj hos tränade individer, enligt studier.

Poelhmann EJ et.al: Influence of caffeine on the resting metabolic rate of exercise-trained and inactive subjects. Med Sci Sports Exercise 1985; 17: 689-94

ja det är jag medveten om men om det samtidigt höjer insulinnivån kan det ju inte vara något vidare att ta innan morgonpromenaden (om man inte behöver det för att orka dvs)