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Visa fullständig version : D-vitamin och ohälsa


ducedo
2013-12-06, 12:25
Low serum concentrations of 25-hydroxyvitamin D (25[OH]D) have been associated with many non-skeletal disorders. However, whether low 25(OH)D is the cause or result of ill health is not known. We did a systematic search of prospective and intervention studies that assessed the effect of 25(OH)D concentrations on non-skeletal health outcomes in individuals aged 18 years or older. We identified 290 prospective cohort studies (279 on disease occurrence or mortality, and 11 on cancer characteristics or survival), and 172 randomised trials of major health outcomes and of physiological parameters related to disease risk or inflammatory status. Investigators of most prospective studies reported moderate to strong inverse associations between 25(OH)D concentrations and cardiovascular diseases, serum lipid concentrations, inflammation, glucose metabolism disorders, weight gain, infectious diseases, multiple sclerosis, mood disorders, declining cognitive function, impaired physical functioning, and all-cause mortality. High 25(OH)D concentrations were not associated with a lower risk of cancer, except colorectal cancer. Results from intervention studies did not show an effect of vitamin D supplementation on disease occurrence, including colorectal cancer. In 34 intervention studies including 2805 individuals with mean 25(OH)D concentration lower than 50 nmol/L at baseline supplementation with 50 μg per day or more did not show better results. Supplementation in elderly people (mainly women) with 20 μg vitamin D per day seemed to slightly reduce all-cause mortality. The discrepancy between observational and intervention studies suggests that low 25(OH)D is a marker of ill health. Inflammatory processes involved in disease occurrence and clinical course would reduce 25(OH)D, which would explain why low vitamin D status is reported in a wide range of disorders. In elderly people, restoration of vitamin D deficits due to ageing and lifestyle changes induced by ill health could explain why low-dose supplementation leads to slight gains in survival.

Vitamin D status and ill health: a systematic review (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70165-7/abstract)

Baskagge
2013-12-08, 01:29
Intressant. Det verkar dyka upp rätt många studier som säger att tillskott av d-vitamin inte har någon effekt eller tvärt om är dåligt för hälsan.

http://marshallprotocol.com/forum39/14033-1.html

Baskagge
2013-12-08, 01:33
http://www.newswise.com/articles/nearly-80-million-americans-won-t-need-vitamin-d-supplements-under-new-guidelines

proteinsynthesis
2013-12-09, 06:22
http://www.newswise.com/articles/nearly-80-million-americans-won-t-need-vitamin-d-supplements-under-new-guidelines

Ok nivåer om 20 ng/ml? Optimala nivåer ska vara runt 70, 100 något.

Jag skulle vilja ha kommentarer från Mats Humble på dessa påståenden.

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Klein
2013-12-09, 07:10
Det finns en ny metanalys i vilken man finner stöd för hypotesen att låga nivåer av d-vitamin kan vara en konsekvens av hälsoproblem snarare än en direkt orsak till dem.

Vitamin D status and ill health: a systematic review (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70165-7/abstract)

Zorgus
2013-12-09, 13:04
Det finns en ny metanalys i vilken man finner stöd för hypotesen att låga nivåer av d-vitamin kan vara en konsekvens av hälsoproblem snarare än en direkt orsak till dem.

Vitamin D status and ill health: a systematic review (http://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70165-7/abstract)

Det kan bli en ond cirkel; dålig hälsa->lågt D-vitamin->ännu sämre hälsa. Sannolikt går den att bryta med tillförsel av D-vitamin. Dr John Cannell som driver Vitamin D Council sade att om han skulle drabbas av en allvarlig infektion skulle han ta en extrastor dos av D-vitamin eftersom mer kommer förbrukas för att få bukt med infektionen, så han är inne på samma spår.

tlk
2013-12-09, 16:29
Ok nivåer om 20 ng/ml? Optimala nivåer ska vara runt 70, 100 något.

Jag skulle vilja ha kommentarer från Mats Humble på dessa påståenden.

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Hint: Han hänger inte på Kolozzeum.

Mejla honom och be om kommentar.

proteinsynthesis
2013-12-09, 19:18
Hint: Han hänger inte på Kolozzeum.

Mejla honom och be om kommentar.

NO shit sherlock... Jag ska titta närmare på studien först, men den verkar inte vara så relevant.

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