tjing
2013-12-03, 18:59
Genetic score of power-speed and endurance track and field athletes.
Abstract
Athletic excelling capability in a specific sport results from the combined influence of hundreds of genetic polymorphisms. The aim of the current study was to characterize athletes' polygenetic scores.
We developed two polygenetic scores:
(a) Power Genetic Distance Score based on two polymorphisms (PGDS2; ACEI / D , ACTN3C / T ) or five polymorphisms (PGDS5; ACTN3C / T , ACEI / D , IL6- 174G / C , NOS3T / C , AGTMET235THR ); and
(b) Endurance Genetic Distance Score based on two polymorphisms (EGDS2; ACEI / D , ACTN3C / T ) or five polymorphisms (EGDS5; PPARGC1AGly482Ser , PPARAintron7G / C , PPARDT294C , NRF2A / C , HIFC / T ).
Eighty-two power-speed athletes, 87 endurance athletes, and 119 nonathletic controls participated in the study. Genomic DNA was extracted from peripheral blood.
Power-speed athletes' mean PGDS2 (46.1) and PGDS5 (29.4) were significantly higher compared with their mean EGDS2 (36.4) and EGDS5 (23.1; P < 0.05, P < 0.01, respectively); and compared with controls' mean PGDS2 (36.6) and PGDS5 (24.2; P < 0.05, P < 0.05, respectively). Endurance athletes' mean EGDS2 (60.3) and EGDS5 (35.3) were significantly higher compared with their mean PGDS2 (26.9) and PGDS5 (21.8; P < 0.001, P < 0.001, respectively); and compared with controls' mean EGDS2 (51.2) and EGDS5 (26.1; P < 0.05, P < 0.001, respectively).
We conclude that polygenetic scores can differentiate power-speed from endurance athletes. Whether these scores may be used to identify elite power-speed or endurance athletes' needs to be addressed in future studies.
Scand J Med Sci Sports. 2013 Nov 27.
http://www.ncbi.nlm.nih.gov/pubmed/24283413
Abstract
Athletic excelling capability in a specific sport results from the combined influence of hundreds of genetic polymorphisms. The aim of the current study was to characterize athletes' polygenetic scores.
We developed two polygenetic scores:
(a) Power Genetic Distance Score based on two polymorphisms (PGDS2; ACEI / D , ACTN3C / T ) or five polymorphisms (PGDS5; ACTN3C / T , ACEI / D , IL6- 174G / C , NOS3T / C , AGTMET235THR ); and
(b) Endurance Genetic Distance Score based on two polymorphisms (EGDS2; ACEI / D , ACTN3C / T ) or five polymorphisms (EGDS5; PPARGC1AGly482Ser , PPARAintron7G / C , PPARDT294C , NRF2A / C , HIFC / T ).
Eighty-two power-speed athletes, 87 endurance athletes, and 119 nonathletic controls participated in the study. Genomic DNA was extracted from peripheral blood.
Power-speed athletes' mean PGDS2 (46.1) and PGDS5 (29.4) were significantly higher compared with their mean EGDS2 (36.4) and EGDS5 (23.1; P < 0.05, P < 0.01, respectively); and compared with controls' mean PGDS2 (36.6) and PGDS5 (24.2; P < 0.05, P < 0.05, respectively). Endurance athletes' mean EGDS2 (60.3) and EGDS5 (35.3) were significantly higher compared with their mean PGDS2 (26.9) and PGDS5 (21.8; P < 0.001, P < 0.001, respectively); and compared with controls' mean EGDS2 (51.2) and EGDS5 (26.1; P < 0.05, P < 0.001, respectively).
We conclude that polygenetic scores can differentiate power-speed from endurance athletes. Whether these scores may be used to identify elite power-speed or endurance athletes' needs to be addressed in future studies.
Scand J Med Sci Sports. 2013 Nov 27.
http://www.ncbi.nlm.nih.gov/pubmed/24283413