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Visa fullständig version : Sarkopeni börjar redan vid 45 års ålder


King Grub
2013-10-17, 08:59
BACKGROUND AND AIMS:

Sarcopenia has been indicated as a reliable marker of frailty and poor prognosis among the oldest individuals. There are only few data on sarcopenia in healthy general population. We evaluated the prevalence of sarcopenia and its association with functional and clinical status in a population of healthy ambulatory subjects over 45 years living at home, in Paris (France).

METHODS:

This study was conducted selecting all ambulatory participants (n = 1,445) aged 45 years and older from October 2008 to September 2011, consulting in the Institute of Physiology (Institut de Jaeger) from Paris (France) for a functional and muscular evaluation, and did not have limitations to moderate physical exercise. All were healthy people. All subjects performed a medical examination, associated with evaluation of muscle mass (body composition assessment using dual-energy X-ray absorptiometry) and of muscle function (by hand grip strength). Diagnosis of sarcopenia required the documentation of low muscle mass with low muscle strength according to the current international consensus definition of sarcopenia.

RESULTS:

From 1,421 participants (553 males and 868 females) definitively enrolled, 221 subjects (135 females and 86 males) (15.5 %) were identified as sarcopenic. Results from multivariate logistic regression models showed that sarcopenia was inversely associated with BMI with those participants with BMI higher than 22 kg/m2 showing a lower risk of sarcopenia relative to those with BMI less than 21 kg/m2 (OR 0.72; 95 % CI 0.60-0.91). Similarly, probability of sarcopenia was lower among subjects involved in leisure physical activities for 3 h or more per week (OR 0.45; 95 % CI 0.24-0.93). According to the category of age [45-54; 55-64; 65-74; 75-84 and 85 years or more], the prevalence of sarcopenia in women increase from 9.1; 12.7; 14.5; 19.4; to 33.3 %, respectively. For the men, the percentage of sarcopenia increase with aging from 8.6; 15.6; 13.6; 63.8 to 45.5 %, respectively.

CONCLUSIONS:

The present study suggests that among healthy ambulatory subjects over 45 years living at home, sarcopenia is frequent, even to the youngest subjects of the studied population, taking place from 9 % from 45 years, until 64.3 % for the subjects over 85 years. Our findings support the hypothesis that muscle mass and function are associated with BMI and physical activity, whatever the age of the subject.

Aging Clin Exp Res. 2013 Oct 16. Prevalence of sarcopenia among healthy ambulatory subjects: the sarcopenia begins from 45 years.

Ram Dass
2013-10-17, 10:27
Som jag tolkar det påstår du att det börjar efter 45 års ålder, men enligt wikipedia (http://en.wikipedia.org/wiki/Sarcopenia) så börjar det redan efter 25 års ålder?

King Grub
2013-10-17, 10:29
1. Det är inte jag som utfört studien.

2. Tycker du att:

"Maximum attainable strength peaks in mid-twenties and declines thereafter.[citation needed]" är en bra källa?

Ram Dass
2013-10-17, 10:35
1. Plumpt uttryckt av mig.

2. Nej, bra att du kunde göra det klarare för mig.

Tack!

pezrulezhaakon
2013-10-17, 12:00
Detta snackade Michail Tonkonogi om för flera år sedan. Muskelförlust främst av typ 2 i benen. Män kan bromsa förlusten bättre än kvinnor.

Bossebäver
2013-10-17, 17:37
Väldigt intressant läsning.

Hur ser det ut på studiefronten med regelbundet tränande individer? Kan dem hålla åldern på rätt sida stängslet?

"Maximum attainable strength peaks in mid-twenties and declines thereafter.[citation needed]" är en bra källa?

Finns det några siffror på när detta scenario inträffar eller skiftar dom genetiska förutsättningarna per individ för mycket?

Hur förklarar studien att Rocky kunde ge en världsmästare en hård match i Rocky 6?:O

major Pectoralis
2013-10-17, 17:57
Angående 25 så gäller det inte sarkopeni. Vill dock minnas att det står att styrkan toppar kring 25 (-30) i Wilmore och Costill: Physiology of Sport and Exercise

Kan vara därifrån det kommer.

Beror väl på hur man mäter också; Tränade, otränade etc.

Greppstyrka kan vara en metod men den brukar hålla sig på topp någonstans 25-40 (i större studier, inte nödvändigtvis på individnivå).

maqan
2013-10-17, 19:43
Hur ser det ut på studiefronten med regelbundet tränande individer?

Det kom ju en studie på äldre triatleter där man såg att de behöll muskelmassan ganska så väl vad jag kan minnas. Grub kanske kan gräva fram den tråden.

King Grub
2013-10-17, 19:46
Det kom ju en studie på äldre triatleter där man såg att de behöll muskelmassan ganska så väl vad jag kan minnas. Grub kanske kan gräva fram den tråden.

Aging is commonly associated with a loss of muscle mass and strength, resulting in falls, functional decline, and the subjective feeling of weakness. Exercise modulates the morbidities of muscle aging. Most studies, however, have examined muscle-loss changes in sedentary aging adults. This leaves the question of whether the changes that are commonly associated with muscle aging reflect the true physiology of muscle aging or whether they reflect disuse atrophy. This study evaluated whether high levels of chronic exercise prevents the loss of lean muscle mass and strength experienced in sedentary aging adults. A cross-section of 40 high-level recreational athletes ("masters athletes") who were aged 40 to 81 years and trained 4 to 5 times per week underwent tests of health/activity, body composition, quadriceps peak torque (PT), and magnetic resonance imaging of bilateral quadriceps. Mid-thigh muscle area, quadriceps area (QA), subcutaneous adipose tissue, and intramuscular adipose tissue were quantified in magnetic resonance imaging using medical image processing, analysis, and visualization software. One-way analysis of variance was used to examine age group differences. Relationships were evaluated using Spearman correlations. Mid-thigh muscle area (P = 0.31) and lean mass (P = 0.15) did not increase with age and were significantly related to retention of mid-thigh muscle area (P < 0.0001). This occurred despite an increase in total body fat percentage (P = 0.003) with age. Mid-thigh muscle area (P = 0.12), QA (P = 0.17), and quadriceps PT did not decline with age. Specific strength (strength per QA) did not decline significantly with age (P = 0.06). As muscle area increased, PT increased significantly (P = 0.008). There was not a significant relationship between intramuscular adipose tissue (P = 0.71) or lean mass (P = 0.4) and PT. This study contradicts the common observation that muscle mass and strength decline as a function of aging alone. Instead, these declines may signal the effect of chronic disuse rather than muscle aging. Evaluation of masters athletes removes disuse as a confounding variable in the study of lower-extremity function and loss of lean muscle mass. This maintenance of muscle mass and strength may decrease or eliminate the falls, functional decline, and loss of independence that are commonly seen in aging adults.

Phys Sportsmed. 2011 Sep;39(3):172-8. Chronic exercise preserves lean muscle mass in masters athletes.

https://physsportsmed.org/doi/10.3810/psm.2011.09.1933

En MRI på quadriceps:

http://sweatscience.com/wp-content/uploads/2012/01/triathlete-aging-muscle-519x1024.jpg

maqan
2013-10-17, 19:48
Phys Sportsmed. 2011 Sep;39(3):172-8. Chronic exercise preserves lean muscle mass in masters athletes.

https://physsportsmed.org/doi/10.3810/psm.2011.09.1933

Du är en ängel.

major Pectoralis
2013-10-17, 20:00
Den var riktigt intressant !

pezrulezhaakon
2013-10-17, 20:19
Bossebäver

Sålänge du håller dig hyfsat aktiv och använder den styrkan du har med jämna mellanrum, så får du behålla muskelmassan länge.
Det som är en stark bidragande orsak till muskelförlusten förutom inaktivitet är att nivån av könshormon naturligt minskar med stigande ålder.

Finns en del studier som visat att de personer som minskat mängden typ 2 fibrer i främst benen, har istället ökat antalet typ 1. Det har att göra med att vissa neuroner som normalt styrt en typ 2 fiber, "konverteras" till att styra typ ett fibrer istället.