handdator

Visa fullständig version : Kardiovaskulära riskmarkörer vid fem dagars försämrad sömn


Eddie Vedder
2012-05-02, 11:15
Sleep deprivation is common in western societies and is associated with increased cardiovascular morbidity and mortality in epidemiological studies. However, the effects of partial sleep deprivation on the cardiovascular system are poorly understood. In the present study, we evaluated thirteen healthy male volunteers (age: 31±2 years) monitoring sleep diary and wrist actigraphy during their daily routine for 12 nights. The subjects were randomized and cross-over to 5 nights of control sleep (>7hs) or 5 nights of partial sleep deprivation (<5hs), interposed by 2 nights of unrestricted sleep. At the end of control and partial sleep deprivation periods, heart rate variability (HRV), blood pressure variability (BPV), serum norepinephrine and venous endothelial function (dorsal hand vein technique) were measured at rest in a supine position. The subjects slept 8.0±0.5 and 4.5±0.3 hours during control and partial sleep deprivation periods, respectively (p<0.01). As compared to control, sleep deprivation caused significant increase in sympathetic activity as evidenced by increase in % Low Frequency (LF) (50±15 vs 59±8) and a decrease in % High Frequency (HF) (50±10 vs 41±8) components of HRV, increase in LF band of BPV, and increase in serum norepinephrine (119±46 vs 162±58 ng/ml), as well as a reduction in maximum endothelial dependent venodilatation (100±22 vs 41±20%), (p< 0.05 for all comparisons). In conclusion, five nights of partial sleep deprivation is sufficient to cause significant increase in sympathetic activity and venous endothelial dysfunction. These results may help to explain the association between short sleep and increased cardiovascular risk in epidemiological studies.

http://jap.physiology.org/content/early/2012/04/24/japplphysiol.01604.2011.long

CARDIOVASCULAR EFFECTS OF PARTIAL SLEEP DEPRIVATION IN HEALTHY VOLUNTEERS. J Appl Physiol. 2012 Apr 26. [Epub ahead of print]

Det här är alltså en interventionsstudie. Inte en studie som tittar på hur länge folk sover och i vilken grad de sedan utvecklar olika sjukdomar. Man mäter markörer före testet och efter testet. Alla deltagare fick genomgå interventionen som både kontrollgrupp och interventionsgrupp.

Peter Hansen
2012-05-02, 18:03
Då räcker alltså inte sovmorgonen på lördagen som många verkar hävda!

maqan
2012-05-02, 19:36
Upplever själv en helt annan känsla i kroppen efter ett par dagars dålig sömn, känner mig lite smått uppjagad.