King Grub
2012-04-30, 11:34
Background:
For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.
Methods:
Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC–BMI categories and continuous WC (including WC and WC2) were calculated by the investigators and pooled by means of random-effects models.
Results:
During a 5-year-follow-up of 32 678 men and 25 931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ≥102 cm, women: ≥88 cm) was associated with increased all-cause mortality RRs for those in the ‘healthy’ weight {1.7 [95% confidence interval (CI): 1.2–2.2], 1.7 (95% CI: 1.3–2.3)}, overweight [1.1(95% CI: 1.0–1.3), 1.4 (95%: 1.1–1.7)] and obese [1.1 (95% CI: 1.0–1.3), 1.6 (95% CI: 1.3–1.9)] BMI category compared with the ‘healthy’ weight (20–24.9 kg/m2) and a small WC (<94 cm, men; <80 cm, women) category. Underweight was associated with highest all-cause mortality RRs in men [2.2 (95% CI: 1.8–2.8)] and women [2.3 (95% CI: 1.8–3.1]. We found a J-shaped association for continuous WC with all-cause, cardiovascular (CVD) and cancer, and a U-shaped association with respiratory disease mortality (P < 0.05). An all-cause (CVD) mortality RR of 2.0 was associated with a WC of 132 cm (123 cm) in men and 116 cm (105 cm) in women.
Conclusions:
Our results showed increased mortality risks for elderly people with an increased WC—even across BMI categories— and for those who were classified as ‘underweight’ using BMI. The results provide a solid basis for re-evaluation of WC cut-points in ageing populations.
Int J Epidemiol. 2012 Mar 31. The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. de Hollander EL, Bemelmans WJ, Boshuizen HC, Friedrich N, Wallaschofski H, Guallar-Castillón P, Walter S, Zillikens MC, Rosengren A, Lissner L, Bassett JK, Giles GG, Heim N, Visser M, de Groot LC; for the WC elderly collaborators. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, Department of Statistics and Mathematical Modelling, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany, Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid / IdiPAZ, CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Department of Medicine, Sahlgrenska University Hospital/Östra, Göteborg, Sweden, Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Parkville, Victoria, Australia, Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands and Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
http://www.sahlgrenska.gu.se/aktuellt/nyheter/Nyheter+Detalj//-stort-midjematt-kopplat-till-okad-dodsrisk-hos-aldre.cid1076922
http://ije.oxfordjournals.org/content/early/2012/04/27/ije.dys008.long
For the elderly, the association between waist circumference (WC) and mortality considering body mass index (BMI) remains unclear, and thereby also the evidence base for using these anthropometric measures in clinical practice. This meta-analysis examined the association between WC categories and (cause-specific) mortality within BMI categories. Furthermore, the association of continuous WC with lowest and increased mortality risks was examined.
Methods:
Age- and smoking-adjusted relative risks (RRs) of mortality associated with WC–BMI categories and continuous WC (including WC and WC2) were calculated by the investigators and pooled by means of random-effects models.
Results:
During a 5-year-follow-up of 32 678 men and 25 931 women, we ascertained 3318 and 1480 deaths, respectively. A large WC (men: ≥102 cm, women: ≥88 cm) was associated with increased all-cause mortality RRs for those in the ‘healthy’ weight {1.7 [95% confidence interval (CI): 1.2–2.2], 1.7 (95% CI: 1.3–2.3)}, overweight [1.1(95% CI: 1.0–1.3), 1.4 (95%: 1.1–1.7)] and obese [1.1 (95% CI: 1.0–1.3), 1.6 (95% CI: 1.3–1.9)] BMI category compared with the ‘healthy’ weight (20–24.9 kg/m2) and a small WC (<94 cm, men; <80 cm, women) category. Underweight was associated with highest all-cause mortality RRs in men [2.2 (95% CI: 1.8–2.8)] and women [2.3 (95% CI: 1.8–3.1]. We found a J-shaped association for continuous WC with all-cause, cardiovascular (CVD) and cancer, and a U-shaped association with respiratory disease mortality (P < 0.05). An all-cause (CVD) mortality RR of 2.0 was associated with a WC of 132 cm (123 cm) in men and 116 cm (105 cm) in women.
Conclusions:
Our results showed increased mortality risks for elderly people with an increased WC—even across BMI categories— and for those who were classified as ‘underweight’ using BMI. The results provide a solid basis for re-evaluation of WC cut-points in ageing populations.
Int J Epidemiol. 2012 Mar 31. The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: a meta-analysis of 29 cohorts involving more than 58 000 elderly persons. de Hollander EL, Bemelmans WJ, Boshuizen HC, Friedrich N, Wallaschofski H, Guallar-Castillón P, Walter S, Zillikens MC, Rosengren A, Lissner L, Bassett JK, Giles GG, Heim N, Visser M, de Groot LC; for the WC elderly collaborators. Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, Department of Statistics and Mathematical Modelling, National Institute of Public Health and the Environment, Bilthoven, The Netherlands, Institute of Clinical Chemistry and Laboratory Medicine, University of Greifswald, Germany, Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid / IdiPAZ, CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain, Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands, Department of Medicine, Sahlgrenska University Hospital/Östra, Göteborg, Sweden, Department of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Victoria, Australia, Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Parkville, Victoria, Australia, Department of Health Sciences, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands and Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands.
http://www.sahlgrenska.gu.se/aktuellt/nyheter/Nyheter+Detalj//-stort-midjematt-kopplat-till-okad-dodsrisk-hos-aldre.cid1076922
http://ije.oxfordjournals.org/content/early/2012/04/27/ije.dys008.long