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Visa fullständig version : Emuolja kan hjälpa mot inflammatoriska tarmsjukdomar [studier]


bollio
2012-01-04, 09:25
RESULTS:

Emu oil in DSS-treated rats reduced colonic damage severity compared to DSS-controls (up to threefold; P < 0.001). In DSS-treated rats, crypts in the proximal colon were lengthened by 0.5 ml emu oil (373 ± 18 μm), compared with DSS-controls (302 ± 8 μm); whilst in the distal colon (DSS control: 271 ± 17 μm), crypt depth was greater following 0.5 ml emu oil (352 ± 22 μm) and 1 ml emu oil (341 ± 9 μm) and also when emu oil was administered post-DSS commencement (Group 6: 409 ± 16 μm; P < 0.05). Emu oil did not significantly affect other parameters of colonic architecture.
CONCLUSIONS:

Emu oil improved tissue damage associated with colitis, suggesting its potential as a unique formulation to augment conventional treatment approaches for IBD.

http://www.ncbi.nlm.nih.gov/pubmed/22147247

Abstract

Mucositis resulting from cancer chemotherapy is a serious disorder of the alimentary tract. Emu oil has demonstrated anti-inflammatory properties in animal models of arthritis and wound healing; however, its effects on the intestine remain unknown. We investigated emu oil for its potential to decrease the severity of mucositis in a rat model. Female Dark Agouti rats (110-150 g) were orogastrically gavaged with emu oil (0.5 or 1 ml) or water (1 ml) for 5 d before intraperitoneal injection of 5-fluorouracil (5-FU, 150 mg/kg) or saline (control), and this was continued up to the day of sacrifice (48, 72 and 96 h post 5-FU administration). Histological (villus height, crypt depth (CD) and disease severity score) and biochemical (myeloperoxidase (MPO) activity) parameters were determined in intestinal tissues collected at sacrifice. Sucrase activity in vivo was quantified by the sucrose breath test. Activated neutrophil activity (MPO) in the ileum was significantly decreased by emu oil (0.5 ml, 451 (sem 168) U/g and 1 ml, 503 (sem 213) U/g) compared with 5-FU-treated controls (1724 (sem 431) U/g) 96 h post 5-FU administration. There were also significant increases in CD (152 (sem 8) microm) in the ileum of rats that received 1 ml emu oil at 96 h compared with 5-FU-treated controls (CD (106 (sem 12) microm)). Emu oil did not affect sucrase activity. Emu oil decreased acute ileal inflammation, and improved mucosal architecture in the intestine during recovery from chemotherapy in rats. Further studies investigating the potential benefits of emu oil as a nutritional supplement for the treatment of intestinal disorders are indicated.

http://www.ncbi.nlm.nih.gov/pubmed/20377926

Vox
2012-01-04, 10:58
Trams. Vad är det du vill att vi ska diskutera, råttor med tarmproblem, pajastillskott från australien eller kvacksalveri generellt?

Jag uppskattar att folk tar sig tid att sprida information om relevanta studier men det här var sällsynt korkat. Kopplingen mellan intag av emuolja och hjärnskador bör utredas.

bollio
2012-01-09, 13:59
Det är ju du som är korkad om du tror att försök på andra däggdjur som råttor inte har någon relevans för människan.

Det finns andra fetter som har liknande positiva effekter på matsmältningssystemet hos människan, ex. smör och kokos.

Denna studie är av stor relevans för människor med inflammatoriska sjukdomar i mag-tarm.

Läs på tack.