King Grub
2011-12-31, 11:57
Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1 h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 weeks of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group x training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase (CAT), copper-zinc superoxide dismutase (CuZnSOD) and glutathione peroxidase 1 (GPX1) mRNA expression in the VT group. However, skeletal muscle protein content of catalase, CuZnSOD, or GPX1 was not affected by training or supplementation. In conclusion, our results indicate that although vitamin C and E supplementation may attenuate exercise-induced plasma IL-6 increase, there is no clear additive effect when combined with endurance training.
J Appl Physiol. 2011 Dec 29. Role of Vitamin C and E Supplementation on IL-6 in response to Training.
J Appl Physiol. 2011 Dec 29. Role of Vitamin C and E Supplementation on IL-6 in response to Training.