handdator

Visa fullständig version : Effekt av fenylalanin på artäriellt och venöst blodflöde till och från hjärnan


King Grub
2011-10-11, 11:37
Aim: 

Sympathetic regulation of the cerebral circulation remains controversial. Although intravenous phenylephrine (PE) infusion reduces the near-infrared spectroscopy (NIRS)-determined measure of frontal lobe oxygenation (S(c) O(2) ) and increases middle cerebral artery mean blood velocity (MCA V(mean) ), suggesting α-adrenergic-mediated cerebral vasoconstriction, this remains unconfirmed by evaluation of arterial and venous cerebral blood flow.

Methods: 

We determined S(c) O(2) , MCA V(mean) , and right internal carotid artery (ICA) and internal jugular venous (IJV) blood flow (duplex ultrasound) during infusion of PE in eight supine young healthy men [26 (3) years, 177 (7) cm and 74 (8) kg; mean (SD)].

Results: 

Compared with saline, during infusion of PE, mean arterial pressure increased 26 ± 3% (mean ± SE) and MCA V(mean) by 4·8 ± 1·9% (P<0·05), while S(c) O(2) decreased by 13·7 ± 3·7% (P<0·05) with no significant changes in the arterial oxygen or carbon dioxide tensions. ICA blood flow did not change significantly in response to PE administration (351 ± 12 versus 373 ± 21 ml min(-1) ; P = 0·236), while IJV blood flow increased (443 ± 57 versus 507 ± 58 ml min(-1) ; P = 0·023).

Conclusions: 

These findings confirm that PE induces a reduction in S(c) O(2) measured by NIRS and causes an increase in MCA V(mean) indicative of cerebral arterial vasoconstriction, although ICA was preserved and IJV increased. These results suggest that a decrease in S(c) O(2) during infusion of PE reflects an altered cerebral contribution of arterial versus venous blood to the NIRS signal, although we cannot rule out that an effect of PE on skin blood flow is important.

Clin Physiol Funct Imaging. 2011 Nov;31(6):445-51. The effect of phenylephrine on arterial and venous cerebral blood flow in healthy subjects.

AntonYmous
2011-10-11, 23:06
Vet man om man får ut sådana här mängder fenylalanin i blodet även vid oralt intag? Och är det här en stor effekt relaterat till normala variationer av stimulans?