Visa fullständig version : Cigarettrök försämrar eller eliminerar träningens positiva påverkan på hjärnan
King Grub
2011-03-23, 08:46
Physical exercise and smoking are environmental factors that generally cause opposite health-promoting adaptations. Both physical exercise and smoking converge on mitochondrial adaptations in various tissues, including the pro-oxidant nervous system. Here, we analyzed the impact of cigarette smoking on exercise-induced brain mitochondrial adaptations in the hippocampus and pre-frontal cortex of adult mice. The animals were exposed to chronic cigarette smoke followed by 8 weeks of moderate-intensity physical exercise that increased mitochondrial activity in the hippocampus and pre-frontal cortex in the non-smoker mice. However, mice previously exposed to cigarette smoke did not present these exercise-induced mitochondrial adaptations. Our results suggest that smoking can inhibit some brain health-promoting changes induced by physical exercise.
Neurochem Res. 2011 Mar 22. Cigarette Smoke Inhibits Brain Mitochondrial Adaptations of Exercised Mice.
...Our results suggest that smoking can inhibit some brain health-promoting changes induced by physical exercise.
Fast rubriken din är väl en aning för extremt dragen slutsats med tanke på vad som faktiskt står i abstraktet.
King Grub
2011-03-23, 08:56
Vilka andra anpassningar i hjärnvävnaden tänker du på?
Jag har inte läst din artikel och egentligen var det enda jag reagerade på ordet eliminering i rubriken då jag inte såg något stöd för det i abstraktet.
Vad jag rent spontant kommer att tänka på är de neurologiska anpassningar som träning inducerar genom att uppreglera de neurotropa faktorerna (BDNF) i centrala nervsystemet. Det är fastslaget att dessa spelar stor roll vid neruo- samt angiogenesen i CNS.
Physical exercise induces widespread neurobiological adaptations and improves learning and memory. Most research in this field has focused on hippocampus-based spatial tasks and changes in brain-derived neurotrophic factor (BDNF) as a putative substrate underlying exercise-induced cognitive improvements. Chronic exercise can also be anxiolytic and causes adaptive changes in stress-reactivity. The present study employed a perirhinal cortex-dependent object recognition task as well as the elevated plus maze to directly test for interactions between the cognitive and anxiolytic effects of exercise in male Long Evans rats. Hippocampal and perirhinal cortex tissue was collected to determine whether the relationship between BDNF and cognitive performance extends to this non-spatial and non-hippocampal-dependent task. We also examined whether the cognitive improvements persisted once the exercise regimen was terminated. Our data indicate that 4weeks of voluntary exercise every-other-day improved object recognition memory. Importantly, BDNF expression in the perirhinal cortex of exercising rats was strongly correlated with object recognition memory. Exercise also decreased anxiety-like behavior, however there was no evidence to support a relationship between anxiety-like behavior and performance on the novel object recognition task. There was a trend for a negative relationship between anxiety-like behavior and hippocampal BDNF. Neither the cognitive improvements nor the relationship between cognitive function and perirhinal BDNF levels persisted after 2weeks of inactivity. These are the first data demonstrating that region-specific changes in BDNF protein levels are correlated with exercise-induced improvements in non-spatial memory, mediated by structures outside the hippocampus and are consistent with the theory that, with regard to object recognition, the anxiolytic and cognitive effects of exercise may be mediated through separable mechanisms.
Neurobiol Learn Mem. 2010 BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory.
Att träning inducerar neuro- och angiogenes:
Increased levels of angiogenesis and neurogenesis possibly mediate the beneficial effects of physical activity on hippocampal plasticity. This study was designed to investigate the temporal dynamics of exercise-induced changes in hippocampal angiogenesis and cell proliferation. Mice were housed with a running wheel for 1, 3, or 10 days. Analysis of glucose transporter Glut1-positive vessel density showed a significant increase after 3 days of wheel running. Cell proliferation in the dentate gyrus showed a trend towards an increase after 3 days of running and was significantly elevated after 10 days of physical exercise. Ten days of wheel running resulted in a near-significant increase in the number of immature neurons, as determined by a doublecortin (DCX) staining. In the second part of the study, the persistence of the exercise-induced changes in angiogenesis and cell proliferation was determined. The running wheel was removed from the cage after 10 days of physical activity. Glut-1 positive vessel density and hippocampal cell proliferation were determined 1 and 6 days after removal of the wheel. Both parameters had returned to baseline 24 h after cessation of physical activity. The near-significant increase in the number of DCX-positive immature neurons persisted for at least 6 days, indicating that new neurons formed during the period of increased physical activity had survived. Together these experiments show that the hippocampus displays a remarkable angiogenic and neurogenic plasticity and rapidly responds to changes in physical activity.Hippocampus. 2009 Oct;19 Physical exercise leads to rapid adaptations in hippocampal vasculature: temporal dynamics and relationship to cell proliferation and neurogenesis.
Nu har jag ju som sagt inte läst studien din utan endast abstraktet och det var det jag reagerade på. Även om jag inte har läst något som ger stöd för det så vore det ju inte helt orimligt om inhiberad mitokondriell anpassning i sin tur skulle kunna påverka den plasticitet i neuro- samt angiogenes som jag har tagit upp. Har de undersökt detta så får du gärna berätta, för det vore väldigt intressant.
bearwolf
2011-03-23, 10:41
Neurochem Res. 2011 Mar 22. Cigarette Smoke Inhibits Brain Mitochondrial Adaptations of Exercised Mice.
Går det att läsa hela någonstans, eller är det som i min bransch att man måste vara betalande medlem för att få läsa vettiga papers?
Kanske är en dum fråga men om man inte frågar så får man inget veta.
Vad är det som påverkas positivt i hjärnan av träning?
Så jag vet vad jag går miste om & kanske leder till att jag inser att jag borde sluta röka.
Det där med att konditionen försämras, man stinker & ev dör tidigare verkar tyvärr inte bita på mig.
Vad är det som påverkas positivt i hjärnan av träning?
Så jag vet vad jag går miste om & kanske leder till att jag inser att jag borde sluta röka.
Det där med att konditionen försämras, man stinker & ev dör tidigare verkar tyvärr inte bita på mig.
Ifall du trodde att de där symptomen utöver denna studien är det enda som påverkas av rökning borde du ta dig en titt till
Rikard Jansson
2011-03-23, 16:08
Jag läste "cigarettrök kan försämra eller eliminera träningens positiva påverkan"
Fick fanemig panik
Ifall du trodde att de där symptomen utöver denna studien är det enda som påverkas av rökning borde du ta dig en titt till
Jag har tillräckligt med ångest över att jag röker. Ska göra ett försök till att sluta tänkte jag.
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