Taurinsupplementering minskar oxidativ stress efter excentrisk träning

[King Grub]

Infrequent exercise, typically involving eccentric actions, has been shown to cause oxidative stress and to damage muscle tissue. High taurine levels are present in skeletal muscle and may play a role in cellular defences against free radical-mediated damage. This study investigates the effects of taurine supplementation on oxidative stress biomarkers after eccentric exercise (EE). Twenty-four male rats were divided into the following groups (n = 6): control; EE; EE plus taurine (EE + Taurine); EE plus saline (EE + Saline). Taurine was administered as a 1-ml 300 mg kg(-1) per body weight (BW) day(-1) solution in water by gavage, for 15 consecutive days. Starting on the 14th day of supplementation, the animals were submitted to one 90-min downhill run session and constant velocity of 1·0 km h(-1). Forty-eight hours after the exercise session, the animals were killed and the quadriceps muscles were surgically removed. Production of superoxide anion, creatine kinase (CK) levels, lipoperoxidation, carbonylation, total thiol content and antioxidant enzyme were analysed. Taurine supplementation was found to decrease superoxide radical production, CK, lipoperoxidation and carbonylation levels and increased total thiol content in skeletal muscle, but it did not affect antioxidant enzyme activity after EE. The present study suggests that taurine affects skeletal muscle contraction by decreasing oxidative stress, in association with decreased superoxide radical production

Cell Biochem Funct. 2010 Dec 27. Taurine supplementation decreases oxidative stress in skeletal muscle after eccentric exercise.

[hejhopp79]

Alltså, Taurin fungerar som en antioxidant och är muskelrelaxerande?

Intressant, med tanke på hur billigt det är att köpa. Tror jag har kvar en burk hemma. Brukade även äta det när jag pluggade ibland eftersom det gav mig en grym fokus och lugn.

Har också supplementerat med taurin när jag sprungit och märker att det tar längre tid tills jag får mjölksyra, något jag har för mig finns grund för i vetenskapen?

[ItsAllGenes]

Alltså, Taurin fungerar som en antioxidant och är muskelrelaxerande?

Intressant, med tanke på hur billigt det är att köpa. Tror jag har kvar en burk hemma. Brukade även äta det när jag pluggade ibland eftersom det gav mig en grym fokus och lugn.

Har också supplementerat med taurin när jag sprungit och märker att det tar längre tid tills jag får mjölksyra, något jag har för mig finns grund för i vetenskapen?

Jag hade för mig att man hade sett ett samband mellan Taurininlagring i myocardiet och risk för hjärtinfarkt så körde en pubmed på det och hittade denna:

Taurine in cardiovascular disease.

Zulli A.

School of Biomedical and Health Science, Victoria University, St Albans, Victoria, Australia.
Abstract

PURPOSE OF REVIEW: The shift of modern dietary regimens from 'Mediterranean' to 'western' style is believed to be responsible, in part, for the increase in cardiovascular disease, obesity, type II diabetes and cancer. A classic 'Mediterranean' diet consists of adequate intake of seafood, vegetables, fruit, whole grain and nonpurified monounsaturated vegetable oil. Thus, in humans, dietary intake of seafood is the major source of taurine, as the level of endogenously produced taurine is low.

RECENT FINDINGS: Taurine has been shown to affect coronary artery disease, blood pressure, plasma cholesterol and myocardial function in animal models of human disease. A major role of taurine is to act as an antioxidant and absorb hypochlorous acid but not the oxidative radical. It seems that this beneficial effect of taurine in antioxidant therapy has not been well promoted.

SUMMARY: This review will focus on determining whether taurine could be a factor contributing to the further prevention of heart disease.

Hinner inte läsa nu men ska titta på den sen.

En annan

The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists.

Rutherford JA, Spriet LL, Stellingwerff T.

Dept. of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Abstract

This study examined whether acute taurine (T) ingestion before prolonged cycling would improve time-trial (TT) performance and alter whole-body fuel utilization compared with a control (CON) trial and a placebo (PL) trial in which participants were told they received taurine but did not. Eleven endurance-trained male cyclists (27.2 ± 1.5 yr, 74.3 ± 2.3 kg, 59.9 ± 2.3 ml · kg⁻¹ · min⁻¹; M ± SEM) completed 3 trials in a randomized, crossover, blinded design in which they consumed a noncaloric sweetened beverage with either 1.66 g of T or nothing added (CON, PL) 1 hr before exercise. Participants then cycled at 66.5% ± 1.9% VO(2max) for 90 min followed immediately by a TT (doing 5 kJ of work/kg body mass as fast as possible). Data on fluid administration, expired gas, heart rate, and ratings of perceived exertion were collected at 15-min intervals during the 90-min cycling ride, but there were no differences recorded between trials. There was no difference in TT performance between any of the 3 trials (1,500 ± 87 s). Average carbohydrate (T 2.73 ± 0.21, CON 2.88 ± 0.19, PL 2.89 ± 0.20 g/min) and fat (T 0.45 ± 0.05, CON 0.39 ± 0.04, PL 0.39 ± 0.05 g/min) oxidation rates were unaffected by T supplementation. T ingestion resulted in a 16% increase (5 g, ~84 kJ; p < .05) in total fat oxidation over the 90-min exercise period compared with CON and PL. The acute ingestion of 1.66 g of T before exercise did not enhance TT performance but did result in a small but significant increase in fat oxidation during submaximal cycling in endurance-trained cyclists.

Motsägelsefullt? Först säger de att T supplementeringen inte ökat fettoxidationen för att i nästa mening säga att den gör det?

[hejhopp79]

Hmm, ja det var ju lite suspekt. Försöker läsa om det flera gånger och se om man missat nåt i texten...

Som jag tolkar det såg man inga skillnader vid mätperioderna var 15:e minut, men totalt sett så ökade taurin fettoxidationen under de 90 minuterna som tester pågick? En 16%:ig ökning låter dock mycket, intressant om det stämmer med andra studier.