z_bumbi
2010-02-14, 17:57
J Endocrinol Invest. 2010 Feb 5. [Epub ahead of print]
TWO WEEKLY SESSIONS OF COMBINED AEROBIC AND RESISTANCE EXERCISE ARE SUFFICIENT TO PROVIDE BENEFICIAL EFFECTS IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS AND METABOLIC SYNDROME.
Fatone C, Guescini M, Balducci S, Battistoni S, Settequattrini A, Pippi R, Stocchi L, Mantuano M, Stocchi V, De Feo P.
C.U.R.I.A.MO. (Centro Universitario Ricerca Interdipartimentale Attivitā Motoria/University Research Center on Physical Activity), University of Perugia, Perugia, Italy.
This study was performed to establish whether only two sessions per week of combined aerobic and resistance exercise are enough to reduce HBA1c and to induce changes in skeletal muscle gene expression in DM2 subjects with metabolic syndrome. Eight DM2 subjects underwent a one-year exercise program consisting of two weekly sessions of 140 minutes that combined aerobic (at 55- 70% of VO2max) and resistance circuit training (at 60-80% of 1 RM). Results: The training significantly improved VO2max (from 33.5+/-3.8 ml/Kg/min to 38.2+/-3.5 ml/Kg/min, p=0.0085) and muscle strength (p<0.05). Changes over baseline were significant for HbA1c, reduced by 0.45% (p=0.0084), fasting blood glucose (from 8.8+/-1.5 to 6.9+/-2.2 mmoli/l, p=0.0132), waist circumference (from 98.9+/-4.8 to 95.9+/-4.6 cm, p=0.0054), body weight (from 87.5+/-10.7 to 85.7+/-10.1 Kg, p=0.0375), systolic blood pressure (from 137+/-15 to 126+/-8 mmHg, p=0.0455), total cholesterol (from 220+/-24 to 184+/-13 mg/dl, p=0.0057), and LDL cholesterol (from 150+/-16 to 105+/-15 mg/dl, p=0.0004). Mitochondrial DNA/nuclear DNA ratio at six and twelve months did not change. There was a significant increase of mRNA of PPARgammaafter six months of training (p=0.024); PPARalphamRNA levels were significantly increased at six (p=0.035) and twelve months (p=0.044). The mRNA quantification of other genes measured (MTCO2, COX5b, PGC-1alpha GLUT 4, FOXO-1, CPT-1, LPL and IRS-1) did not show significant changes at six and twelve months. This study suggests that a twice-per-week frequency of exercise is sufficient to improve glucose control and the expression of skeletal muscle PPARgammaand PPARalphain DM2 subjects with metabolic syndrome.
TWO WEEKLY SESSIONS OF COMBINED AEROBIC AND RESISTANCE EXERCISE ARE SUFFICIENT TO PROVIDE BENEFICIAL EFFECTS IN SUBJECTS WITH TYPE 2 DIABETES MELLITUS AND METABOLIC SYNDROME.
Fatone C, Guescini M, Balducci S, Battistoni S, Settequattrini A, Pippi R, Stocchi L, Mantuano M, Stocchi V, De Feo P.
C.U.R.I.A.MO. (Centro Universitario Ricerca Interdipartimentale Attivitā Motoria/University Research Center on Physical Activity), University of Perugia, Perugia, Italy.
This study was performed to establish whether only two sessions per week of combined aerobic and resistance exercise are enough to reduce HBA1c and to induce changes in skeletal muscle gene expression in DM2 subjects with metabolic syndrome. Eight DM2 subjects underwent a one-year exercise program consisting of two weekly sessions of 140 minutes that combined aerobic (at 55- 70% of VO2max) and resistance circuit training (at 60-80% of 1 RM). Results: The training significantly improved VO2max (from 33.5+/-3.8 ml/Kg/min to 38.2+/-3.5 ml/Kg/min, p=0.0085) and muscle strength (p<0.05). Changes over baseline were significant for HbA1c, reduced by 0.45% (p=0.0084), fasting blood glucose (from 8.8+/-1.5 to 6.9+/-2.2 mmoli/l, p=0.0132), waist circumference (from 98.9+/-4.8 to 95.9+/-4.6 cm, p=0.0054), body weight (from 87.5+/-10.7 to 85.7+/-10.1 Kg, p=0.0375), systolic blood pressure (from 137+/-15 to 126+/-8 mmHg, p=0.0455), total cholesterol (from 220+/-24 to 184+/-13 mg/dl, p=0.0057), and LDL cholesterol (from 150+/-16 to 105+/-15 mg/dl, p=0.0004). Mitochondrial DNA/nuclear DNA ratio at six and twelve months did not change. There was a significant increase of mRNA of PPARgammaafter six months of training (p=0.024); PPARalphamRNA levels were significantly increased at six (p=0.035) and twelve months (p=0.044). The mRNA quantification of other genes measured (MTCO2, COX5b, PGC-1alpha GLUT 4, FOXO-1, CPT-1, LPL and IRS-1) did not show significant changes at six and twelve months. This study suggests that a twice-per-week frequency of exercise is sufficient to improve glucose control and the expression of skeletal muscle PPARgammaand PPARalphain DM2 subjects with metabolic syndrome.