Eddie Vedder
2010-01-26, 17:58
Alli och Xenical kanske flera här redan känner till men om inte så är det alltså mediciner vilka agerar som lipashämmare. De hämmar alltså fettspjälkande enzymer (lipaser) och gör att stora delar av ens fettintag bajsas ut.
I den är studien undersökte man 146 överviktiga personer som delades upp i två olika dietgrupper.
Ena dieten bestod av en lågfettkost (<30E%) med kalorirestriktion kombinerat med Orlistat (den aktiva substansen i nämnda mediciner). Den andra var en ketogen lågkolhydratkost för där man inte hade någon som helst kalorirestriktion och den enda "regeln" var att inte överstiga 20 gram kolhydrat/dag.
Resultatet var som följer och den ketogena lågkolhydratkosten var precis lika effektiv för viktnedgång och förbättrade deltagarnas hälsa. Och de slapp förmodligen fettdiarré.:D
Background Two potent weight loss therapies, a low-carbohydrate, ketogenic diet (LCKD) and orlistat therapy combined with a low-fat diet (O + LFD), are available to the public but, to our knowledge, have never been compared.
Methods Overweight or obese outpatients (n = 146) from the Department of Veterans Affairs primary care clinics in Durham, North Carolina, were randomized to either LCKD instruction (initially, <20 g of carbohydrate daily) or orlistat therapy, 120 mg orally 3 times daily, plus low-fat diet instruction (<30% energy from fat, 500-1000 kcal/d deficit) delivered at group meetings over 48 weeks. Main outcome measures were body weight, blood pressure, fasting serum lipid, and glycemic parameters.
Results The mean age was 52 years and mean body mass index was 39.3 (calculated as weight in kilograms divided by height in meters squared); 72% were men, 55% were black, and 32% had type 2 diabetes mellitus. Of the study participants, 57 of the LCKD group (79%) and 65 of the O + LFD group (88%) completed measurements at 48 weeks. Weight loss was similar for the LCKD (expected mean change, –9.5%) and the O + LFD (–8.5%) (P = .60 for comparison) groups. The LCKD had a more beneficial impact than O + LFD on systolic (–5.9 vs 1.5 mm Hg) and diastolic (–4.5 vs 0.4 mm Hg) blood pressures (P < .001 for both comparisons). High-density lipoprotein cholesterol and triglyceride levels improved similarly within both groups. Low-density lipoprotein cholesterol levels improved within the O + LFD group only, whereas glucose, insulin, and hemoglobin A1c levels improved within the LCKD group only; comparisons between groups, however, were not statistically significant.
Conclusion In a sample of medical outpatients, an LCKD led to similar improvements as O + LFD for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.
http://archinte.ama-assn.org/cgi/content/full/170/2/136
A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss. Arch Intern Med. 2010;170(2):136-145.
Tilläggas bör att i båda fallen lyckades de individerna bäst som dessutom deltog i de gruppmöten som erbjöds samt att viktnedgången var störst i början för att sedan avta. Man kan ju alltså inte veta om de kommer gå upp allt igen.
I den är studien undersökte man 146 överviktiga personer som delades upp i två olika dietgrupper.
Ena dieten bestod av en lågfettkost (<30E%) med kalorirestriktion kombinerat med Orlistat (den aktiva substansen i nämnda mediciner). Den andra var en ketogen lågkolhydratkost för där man inte hade någon som helst kalorirestriktion och den enda "regeln" var att inte överstiga 20 gram kolhydrat/dag.
Resultatet var som följer och den ketogena lågkolhydratkosten var precis lika effektiv för viktnedgång och förbättrade deltagarnas hälsa. Och de slapp förmodligen fettdiarré.:D
Background Two potent weight loss therapies, a low-carbohydrate, ketogenic diet (LCKD) and orlistat therapy combined with a low-fat diet (O + LFD), are available to the public but, to our knowledge, have never been compared.
Methods Overweight or obese outpatients (n = 146) from the Department of Veterans Affairs primary care clinics in Durham, North Carolina, were randomized to either LCKD instruction (initially, <20 g of carbohydrate daily) or orlistat therapy, 120 mg orally 3 times daily, plus low-fat diet instruction (<30% energy from fat, 500-1000 kcal/d deficit) delivered at group meetings over 48 weeks. Main outcome measures were body weight, blood pressure, fasting serum lipid, and glycemic parameters.
Results The mean age was 52 years and mean body mass index was 39.3 (calculated as weight in kilograms divided by height in meters squared); 72% were men, 55% were black, and 32% had type 2 diabetes mellitus. Of the study participants, 57 of the LCKD group (79%) and 65 of the O + LFD group (88%) completed measurements at 48 weeks. Weight loss was similar for the LCKD (expected mean change, –9.5%) and the O + LFD (–8.5%) (P = .60 for comparison) groups. The LCKD had a more beneficial impact than O + LFD on systolic (–5.9 vs 1.5 mm Hg) and diastolic (–4.5 vs 0.4 mm Hg) blood pressures (P < .001 for both comparisons). High-density lipoprotein cholesterol and triglyceride levels improved similarly within both groups. Low-density lipoprotein cholesterol levels improved within the O + LFD group only, whereas glucose, insulin, and hemoglobin A1c levels improved within the LCKD group only; comparisons between groups, however, were not statistically significant.
Conclusion In a sample of medical outpatients, an LCKD led to similar improvements as O + LFD for weight, serum lipid, and glycemic parameters and was more effective for lowering blood pressure.
http://archinte.ama-assn.org/cgi/content/full/170/2/136
A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss. Arch Intern Med. 2010;170(2):136-145.
Tilläggas bör att i båda fallen lyckades de individerna bäst som dessutom deltog i de gruppmöten som erbjöds samt att viktnedgången var störst i början för att sedan avta. Man kan ju alltså inte veta om de kommer gå upp allt igen.