omega 3 - lederna

[thunberg]

Jag undrar om det är någon som har egna erfarenheter av förbättring av knä/fotleder efter att ni ätit extra mycket omega 3.

Har ni även andra tips som motverkar ledbrosk och allt som motverkar led ont i knä/fotleder är det högst välkommet!

[Anders The Peak]

Jag undrar om det är någon som har egna erfarenheter av förbättring av knä/fotleder efter att ni ätit extra mycket omega 3.

Har ni även andra tips som motverkar ledbrosk och allt som motverkar led ont i knä/fotleder är det högst välkommet!
Fiskolja dämpar den inflammatoriska processen och ger lindring av besvären. Det är möjligt att det ger en förbättring över tid men det kan jag inte ge något svar på. Utan det handlar mer om vad grundproblemet är om det är en artros(förslitningsskada) brukar det vara något man får leva med. Om det är en akut skada så kan det underlätta/påskynda läkningsprocessen.

[Eddie Vedder]

Dethar studerats väldigt mycket hur fiskolja och konsumtion av fet fisk kan tänkas förebygga utveckling av artros. Det verkar både som fiskoljan och fiskkonsumtionen kan vara positiv.

Att studier finns på just SUPPLEMENTERING är ju viktigt i sammanhanget om man vill försöka se just EPA och DHA som den primära fördelen och inte andra komponenter i fet fisk (som D-vitamin t.ex.).

Background: Intake of fish oil and oily fish has been reported to improve clinical symptoms in people who have rheumatoid arthritis. Whether the intake of oily fish and fish oil might also protect against the development of rheumatoid arthritis is not known.

Objective: We investigated the association between intake of oily fish and fish oil supplements and the risk of rheumatoid arthritis in a population-based case-control study.

Methods: The study comprised 1889 incident cases of rheumatoid arthritis and 2145 randomly selected controls recruited from a geographically defined area of Sweden during 1996-2005. Data on the consumption of oily fish and fish oil supplements 5 years preceding enrollment had been obtained through a questionnaire. We calculated odds ratios (ORs) for the development of rheumatoid arthritis, using logistic regression to adjust for age, residential area, body mass index, smoking, and alcohol consumption.

Results: Compared with subjects who never or seldom consumed oily fish, the OR for developing rheumatoid arthritis was 0.8 (95% confidence interval = 0.6-1.0) for subjects who consumed oily fish 1-7 times a week. The results did not change notably when stratifying the cases for rheumatoid factor or for antibodies to citrullinated peptide antigens. Similar results were seen for subjects consuming oily fish 1-3 times a month. Cases and controls did not differ in their consumption of fish oil supplements.

Conclusion: Intake of oily fish was associated with a modestly decreased risk of developing rheumatoid arthritis.


Dietary fish and fish oil and the risk of rheumatoid arthritis. Epidemiology. 2009 Nov;20(6):896-901.

Eicosanoids derived from the n-6 fatty acid, arachidonic acid, and the cytokines interleukin-1beta and tumour necrosis factor-alpha are involved in the signs and symptoms of inflammatory joint disease, as well as the cartilage degradation seen in established rheumatoid arthritis (RA). Then n-3 fatty acids in fish and fish oil can inhibit production of both eicosanoid and cytokine inflammatory mediators and therefore, have the potential to modify RA pathology. Epidemiological studies suggest that fish intake may be preventive for RA and double-blind placebo-controlled studies demonstrate that dietary fish oil can alleviate the signs and symptoms of RA. The implementation of these findings will require among other things, a range of n-3 fat enriched foods, as well as physician awareness of the possibilities for dietary n-3 fat increases to be used as adjunctive therapy in RA.

Dietary n-3 fats as adjunctive therapy in a prototypic inflammatory disease: issues and obstacles for use in rheumatoid arthritis. Prostaglandins Leukot Essent Fatty Acids. 2003 Jun;68(6):399-405.

The beneficial properties of fish oil are well known and are related to its fatty acid composition rich in omega-3 polyunsaturated fatty acids. In the last years a variety of epidemiological and clinical studies have demonstrated the efficacy of fish oil supplementation in the rheumatic diseases, in particular in rheumatoid arthritis. The anti-inflammatory effects of fish oil are linked to the production of alternative eicosanoids, to the reduction of proinflammatory cytokines, to the inhibition of the activation of T lymphocytes and of catabolic enzymes. Fish oil supplementation could represent a valuable support to the traditional pharmacological treatment of rheumatoid arthritis.

[Fish oil supplementation in rheumatoid arthritis]. Reumatismo. 2008 Jul-Sep;60(3):174-9.

OBJECTIVE: To examine the potential for dietary n-3 fats to be component of therapy for rheumatoid arthritis (RA). METHODS: Studies of encapsulated fish oil use in RA were reviewed and critiqued, and possible biochemical mechanisms for fish oil effects were examined. The potential for use of n-3 fats was evaluated within a dietary framework rather than a quasi-pharmaceutical framework. RESULTS: There is consistent evidence from double-blind, placebo-controlled clinical trials that dietary n-3 fats, supplied as fish oil, can have beneficial effects in RA. The beneficial effects appear modest, but their size and extent may have been moderated by common trial design factors such as high n-6 polyunsaturated fat diets and concurrent antiinflammatory drug use. Mechanisms for the clinical effects of n-3 fats in RA may involve their ability to suppress production of inflammatory mediators, including n-6 eicosanoids and proinflammatory cytokines. Suppression of n-6 eicosanoid and cytokine production will be possible using foodstuffs that are rich in n-3 fats and poor in n-6 fats. CONCLUSIONS: There are many overlapping biochemical effects of n-3 fatty acids and antiinflammatory pharmaceuticals that could explain the clinical actions of n-3 fats in RA. They suggest that there is the potential for complementarity between drug therapy and dietary choices that increase intake of n-3 fats and decrease intake of n-6 fats. In particular, there is the potential for drug-sparing effects. Future studies with n-3 fats in RA need to address the fat composition of the background diet and the issue of concurrent drug use

Dietary n-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum. 1997 Oct;27(2):85-97.

[Hillseeker]

Jag har iofs inte haft allvarliga problem med leder eller någon som helst diagnos på dessa men jag har haft en viss stelhet, ömhet samt en hel del knakande som kommit genom åren. Mina problem om man nu kan kalla det för problem ha i det närmaste försvunnit tack vara omega i form av kosttillskott samt genom vanlig mat.

[Vicotnik]

Jag har alltid haft lite problem med leder, främst axlarna. Men efter lite drygt två månader med ett kosttillskott innehållande glucosamine, chondroitin och MSM (engelska termer, läser vad som står på förpackningen) har besvären minskat betydligt.
Kan kanske vara värt att prova.