King Grub
2009-12-23, 12:46
Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for eight weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and GASP-1 (growth and differentiation factor-associated serum perotein-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 yr) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of three days per week of training for 8 weeks, each session including three sets of eight to ten repetitions at 60-70% of 1RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4(th) and 8(th) weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (P<0.05), but had not additional effect on GASP-1(P>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.
Mol Cell Endocrinol. 2009 Dec 18. Effects of oral creatine and resistance training on serum myostatin and GASP-1.
Mol Cell Endocrinol. 2009 Dec 18. Effects of oral creatine and resistance training on serum myostatin and GASP-1.