Dåligt med mycket protein! - Avskräckande för oss tränande?

[TSullivanM]

http://www.aftonbladet.se/kropphalsa/article5997524.ab

[Alfred Nobel]

Aftonbladet är dåligt. Ska läsa länken!

Dom har matat möss ju... Fungerar deras hjärna som vår hjärna?

[CrazyJoeDavola]

Möss används ju ofta i olika försök, och det är nog inga tillfälligheter.

[Apos78]

Vad är definitionen för proteinrik mat? Inte bara gällande denna artikel utan mer generellt. Vad anser ni själva? Och hur mycket anser ni er behöva?

[christian9]

Aftonbladet och jag blir misstänksam direkt. Atkinsliknande diet på möss - hur vet dom att det var just proteinintaget som ökade risken för Alzheimer? Kan det inte lika gärna vara avsaknaden av kolhydrater eller det höga intaget mättat fett?

Borde inte det faktum att mössen åt enligt atkins i sig innebära att de hade mindre hjärna än genomsnittet redan från början? ;)

[Fatcan]

Haha, "märks på Doktor Dahlqvist"

[Eddie Vedder]

För den som hellre kollar upp vad studien handlar om än på ren rutin spyr galla över Aftonbladet finns abstraktet och länk till fullängdaren här:

Abstract (provisional)

Objective
Alzheimer's disease (AD) is a progressive neurodegenerative disease of the central nervous system (CNS). Recently, an increased interest in the role diet plays in the pathology of AD has resulted in a focus on the detrimental effects of diets high in cholesterol and fat and the beneficial effects of caloric restriction. The current study examines how dietary composition modulates cerebral amyloidosis and neuronal integrity in the TgCRND8 mouse model of AD.

Methods
From 4 wks until 18 wks of age, male and female TgCRND8 mice were maintained on one of four diets: (1) reference (regular) commercial chow; (2) high fat/low carbohydrate custom chow (60 kcal% fat/ 30 kcal% protein/ 10 kcal% carbohydrate); (3) high protein/low carbohydrate custom chow (60 kcal% protein/ 30 kcal% fat/ 10 kcal% carbohydrate); or (4) high carbohydrate/low fat custom chow (60 kcal% carbohydrate/ 30 kcal% protein/ 10 kcal% fat). At age 18 wks, mice were sacrificed, and brains studied for (a) wet weight; (b) amyloid beta content by ELISA; (c) amyloid plaque burden; (d) stereologic analysis of selected hippocampal subregions.

Results
Consistent with prior reports, animals receiving a high fat diet showed increased brain levels of amyloid beta, although we detected no effect on plaque burden. Unexpectedly, brains of mice fed a high protein/low carbohydrate diet were 5% lower in weight than brains from all other mice (p=0.032). In an effort to identify regions that might link loss of brain mass to cognitive function, we studied neuronal density and volume in hippocampal subregions. Neuronal density and volume in the hippocampal CA3 region of TgCRND8 mice tended to be lower in TgCRND8 mice receiving the high protein/low carbohydrate diet than in those receiving the regular chow (p=0.073 and p=0.069, respectively). Neuronal density and volume were preserved in CA1 and in the dentate gyrus. Dissociation of amyloid beta changes from brain mass changes raises the possibility that diet plays a role not only in modulating amyloidosis but also in modulating neuronal vulnerability. However, in the absence of a study of the effects of a high protein/low carbohydrate diet on nontransgenic mice, one cannot be certain how much, if any, of the loss of brain mass exhibited by high protein/low carbohydrate diet-fed TgCRND8 mice was due to an interaction between cerebral amyloidosis and diet. Given the recent evidence that certain factors favor the maintenance of cognitive function in the face of substantial structural neuropathology, we propose that there might also exist factors that sensitize brain neurons to some forms of neurotoxicity, including, perhaps, amyloid neurotoxicity. Identification of these factors could help reconcile the poor clinicopathological correlation between cognitive status and structural neuropathology, including amyloid pathology.


http://www.molecularneurodegeneration.com/content/pdf/1750-1326-4-40.pdf

Pedrini S et al. Dietary composition modulates brain mass and amyloid beta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration 2009, 4:40

Och här kan ni läsa artikeln i Daily Telegraph:

http://www.telegraph.co.uk/health/healthnews/6387851/High-protein-diets-could-cause-Alzheimers.html

Haha, "märks på Doktor Dahlqvist"

Hon äter inte Atkins. Och om det är högt proteinintag som är riskfaktorn så lever hon knappast farligt. Kolozzeumgenomsnittet däremot.