Stora muskler ger minskad cancerrisk, artikel i Aktiv träning

[maRRtin]

Läste senaste utgåvan av Aktiv träning igår.

Där stod det i en artikel att personer med större muskelmassa löpte upp till 40% mindre risk för att drabbas av cancer. Det var en ganska stor studie om jag inte minns helt fel, kommer såklart inte ihåg vem som hade utfört studien.

Har ju trott att en låg kroppsvikt är att föredra när det handlar om minska risken för att drabbas av cancer.
Någon som vet vilken studie det handlar om?

[mattilainen]

intressant. Vill också veta

[LadyG]

Det var ett projekt från Karolinska Institutet. 8 677 än i åldern 20-82 år följdes under en 20-årsperiod, stod det i tidningen.

[King Grub]

http://cebp.aacrjournals.org/cgi/reprint/18/5/1468

http://www.bmj.com/cgi/content/abstract/337/jul01_2/a439?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Ruiz%2C+JR&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

[jwzrd]

Läste jag inte för några månader sedan att större muskelmassa gav en högre risk för cancer?!

[King Grub]

Den här studien visar att större styrka ger lägre cancerrisk. Inte hög kroppsvikt eller stor muskelmassa.

[Eddie Vedder]

Läste jag inte för några månader sedan att större muskelmassa gav en högre risk för cancer?!

Jo det stämmer. Här undersöktes just maxstyrka och allmän dödlighet, med särskild inriktning på kardiovaskulär sjukdom och cancer, hos 8762 indivder mellan 20 och 80 års ålder under 18.9 år.

Styrkan mättes enligt följande:

We assessed muscular strength in the upper and lower body using a standardised strength testing protocol of variable resistance weight machines (Universal Equipment, Cedar Rapids, IA, USA).31 32 Upper body strength was assessed with a one repetition maximum supine bench press, and lower body strength was assessed with a one repetition maximum seated leg press. Initial loads were 70% of body weight for the bench press and 100% for the leg press. After a brief rest period, we added increments of 2.27 kg to 4.54 kg until maximal effort was achieved for each lift, usually after five or fewer trials. Participants were able to lift the initial load at least one time. They were instructed on proper breathing and lifting form for each movement. The intraclass correlation coefficient for one repetition maximum bench press and leg press was 0.90 and 0.83, respectively, in a subgroup of 246 men who underwent two muscular strength assessments within one year.31

We computed a score for muscular strength by combining the standardised values of bench and leg presses. Each of these variables was standardised using the formula: standardised value=(value–mean)/standard deviation. We calculated the score separately for each age group (20-29, 30-39, 40-49, 50-59, and 60). The score for muscular strength was calculated as the mean of the two standardised scores (bench and leg presses). For analysis we used thirds of the age specific composite strength score.


Lite från diskussionen:

We investigated the association between standardised measures of upper and lower body muscular strength and disease specific risk of mortality in a large cohort of men with extensive follow-up. Muscular strength and cardiorespiratory fitness were moderately correlated (age adjusted partial r=0.33), suggesting that the association between muscular strength and risk of death from cancer works at least partially through different mechanisms than those associated with the protective effects of cardiorespiratory fitness. That the association between muscular strength and risk of death from cardiovascular disease was not significantly independent of cardiorespiratory fitness highlights the key role of cardiorespiratory fitness in the development of cardiovascular disease in men; however, their combined effects cannot be easily disentangled in an observational study. In this cohort the number of deaths from cardiovascular disease was lower than that from cancer (145 and 199, respectively). This may have reduced the statistical power to detect a significant independent association between muscular strength and risk of death from cardiovascular disease.


[...]

The apparent protective effect of muscular strength against risk of death might be due to muscular strength in itself, to muscle fibre type or configuration, or as a consequence of regular physical exercise, specifically resistance exercise. Muscle fibre type and configuration has a genetic component and influences strength, yet it is clear that resistance type physical activities are major determinants of muscular strength.5 48 We have previously reported a strong and positive association between the frequency of self reported resistance exercise and maximal muscular strength in men enrolled in the aerobics centre longitudinal study—that is, the higher the participation in resistance exercise the higher the muscular strength.32 This observation suggests that the measurements of muscular strength obtained in the present study provide an adequate representation of the resistance exercise habits in our cohort. Results from intervention studies indicate that resistance training enhances muscular strength and endurance, muscle mass, functional capacity, daily physical activity, risk profile for cardiovascular disease, and quality of life.5 These factors are well known predictors of higher risk of mortality. The benefits of resistance training are evident in men and women, young adults, and older people, in overweight and obese adults as well as in people of normal weight, and in people with or without disability, or with cardiovascular disease.5 We observed an inverse association between muscular strength and risk of death from all causes and cancer in older men (60 years) and younger men (<60 years). This suggests that older men may also benefit from having higher levels of muscular strength. In older men, functional performance becomes more directly dependent on strength, as these men also experience age associated declines in muscle mass and consequently in muscular strength.