Eddie Vedder
2008-11-05, 15:43
Abstract
Background/Objectives: Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-6/n-3 PUFA ratio on cardiovascular risk factors and resting energy expenditure.
Subjects and methods: Ten-week dietary intervention in 17 healthy subjects. Dietary intake, euglycemic hyperinsulinemic clamp, indirect calorimetry, lipid profile, hormones, inflammatory markers and erythrocyte membrane fatty acid composition were recorded before and at the end of the intervention. Comparisons are between baseline and post-treatment levels.
Results: Dietary records of the linoleic acid/-linolenic acid ratio (baseline: 32.2 (s.d. 3.7) vs post-intervention: 2.2 (s.d. 0.1), P<0.0001) and erythrocyte membrane fatty acid composition reflected good compliance. Dietary intervention was associated with significant reductions in TNF- (baseline: 2.2 (s.d. 0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d. 0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7), post-intervention: 7.6 (s.d. 0.6) g/ml, P=0.02). Fasting lipid oxidation was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1) mg/kg.min, P=0.01), whereas glucose oxidation decreased in both fasting (baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg.min, P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1), post-intervention: 3.3 (s.d. 0.1) mg/kg.min, P=0.04). Insulin sensitivity was not affected by the intervention.
Conclusion: A decreased n-6/n-3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles.
http://www.nature.com/ejcn/journal/v62/n11/full/1602857a.html
Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects. European Journal of Clinical Nutrition (2008) 62, 1287–1293
Mot bakgrund av kunskap om snedfördelning mellan omega-6/omega-3 i den västerländska kosten samt de hälsomässiga konsekvenserna en sådan kost kan ha på människa så testade man att med en tämligen enkel kostomläggning jämna ut den fördelningen hos 17 friska personer under 10 veckor.
Resultaten visade positiva effekter på flera metabola hälsofaktorer som man kan läsa mer detaljerat om i fullängdaren.
Our results support an impact of n-6/n-3 PUFA ratio change at various levels, including favourable anti-inflammatory and lipid profiles. The observed modulation of adiponectin and cytokine levels by a simple nutritional approach independent of changes in body weight, if confirmed among obese and insulin-resistant subjects, would represent an attractive approach in terms of the prevention of diabetes and cardiovascular disease.
Såhär såg kosten ut:
Diet and experimental design
The protocol consisted of a 10-week dietary intervention. The foods and ingredients selected for the diet were designed to increase the dietary content of n-3 fatty acids and to decrease n-6 fatty acids. Rapeseed oil was supplied with a daily intake of 20 ml (1.7 g/day of ALA). The study subjects were also instructed to augment their fish consumption to three fish meals per week (100 g of salmon, tuna, mackerel, herring and sardines) in place of their habitual meat intake, providing a mean of 1.25 g/day of EPA and DHA. Advice was provided by a trained dietician twice before the dietary intervention and again after 1 month regarding the avoidance of foods containing high amounts of n-6 PUFA, vegetable oils (except rapeseed and olive) and their derivative products (potato chips, certain nuts and so on). Special emphasis was placed on qualitative but not quantitative modification of their habitual diet.
Background/Objectives: Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-6/n-3 PUFA ratio on cardiovascular risk factors and resting energy expenditure.
Subjects and methods: Ten-week dietary intervention in 17 healthy subjects. Dietary intake, euglycemic hyperinsulinemic clamp, indirect calorimetry, lipid profile, hormones, inflammatory markers and erythrocyte membrane fatty acid composition were recorded before and at the end of the intervention. Comparisons are between baseline and post-treatment levels.
Results: Dietary records of the linoleic acid/-linolenic acid ratio (baseline: 32.2 (s.d. 3.7) vs post-intervention: 2.2 (s.d. 0.1), P<0.0001) and erythrocyte membrane fatty acid composition reflected good compliance. Dietary intervention was associated with significant reductions in TNF- (baseline: 2.2 (s.d. 0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d. 0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7), post-intervention: 7.6 (s.d. 0.6) g/ml, P=0.02). Fasting lipid oxidation was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1) mg/kg.min, P=0.01), whereas glucose oxidation decreased in both fasting (baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg.min, P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1), post-intervention: 3.3 (s.d. 0.1) mg/kg.min, P=0.04). Insulin sensitivity was not affected by the intervention.
Conclusion: A decreased n-6/n-3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles.
http://www.nature.com/ejcn/journal/v62/n11/full/1602857a.html
Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects. European Journal of Clinical Nutrition (2008) 62, 1287–1293
Mot bakgrund av kunskap om snedfördelning mellan omega-6/omega-3 i den västerländska kosten samt de hälsomässiga konsekvenserna en sådan kost kan ha på människa så testade man att med en tämligen enkel kostomläggning jämna ut den fördelningen hos 17 friska personer under 10 veckor.
Resultaten visade positiva effekter på flera metabola hälsofaktorer som man kan läsa mer detaljerat om i fullängdaren.
Our results support an impact of n-6/n-3 PUFA ratio change at various levels, including favourable anti-inflammatory and lipid profiles. The observed modulation of adiponectin and cytokine levels by a simple nutritional approach independent of changes in body weight, if confirmed among obese and insulin-resistant subjects, would represent an attractive approach in terms of the prevention of diabetes and cardiovascular disease.
Såhär såg kosten ut:
Diet and experimental design
The protocol consisted of a 10-week dietary intervention. The foods and ingredients selected for the diet were designed to increase the dietary content of n-3 fatty acids and to decrease n-6 fatty acids. Rapeseed oil was supplied with a daily intake of 20 ml (1.7 g/day of ALA). The study subjects were also instructed to augment their fish consumption to three fish meals per week (100 g of salmon, tuna, mackerel, herring and sardines) in place of their habitual meat intake, providing a mean of 1.25 g/day of EPA and DHA. Advice was provided by a trained dietician twice before the dietary intervention and again after 1 month regarding the avoidance of foods containing high amounts of n-6 PUFA, vegetable oils (except rapeseed and olive) and their derivative products (potato chips, certain nuts and so on). Special emphasis was placed on qualitative but not quantitative modification of their habitual diet.