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Visa fullständig version : Effekter av CLA?


Linnet
2003-06-28, 16:09
Är lite intresserad av att prova CLA och undrar vilka effekter folk har fått av det? Försöker nu styra upp kosten och äta nyttigt (vilket jag gör efter bästa förmåga) och tycker mig redan märka lite resultat. Är väl mer intresserad av att prova CLA för att se om det har effekt än för att jag inte skulle lyckas annars. Så fira av kommentarer alla ni som provat produkten och säg vad ni tycker, prisvärt eller skräp.

Castro
2003-06-28, 16:24
Det finns typ oändligt med trådar som tar upp detta tillskott. Använd sökfunktionen istället.

Linnet
2003-06-28, 16:42
Du har så rätt Castro, det finns oändligt med trådar som jag EFTER att jag gått igenom fann inte besvarade frågan om folks erfarenheter på ett för mig tillfredställande sätt! Därför skapade jag denna tråden. Tycker du att den är ointressant eller onödig så behöver du inte kladda ner den med misriktade tillrättavisningar utan läs en god bok istället!:smash:

Fortfarande fritt fram att säga vilka effekter ni har fått utav CLA och om ni rekommenderar detta eller inte.

AciDBL00D
2003-06-28, 16:54
Jag fick en burk _BILLIGT_ ingen deff eller nått sånt åt som vanligt men käkade kapslarna 3-4 om dagen (1000mg) jag märkte ingenting. Men jag var inte så seriös heller ingen deff jag gick på eller nått sånt

Karelin
2003-06-28, 17:28
har kört igenom 4 burkar av ett billigt märke... åt 6g om dagen delat på 3 tillfällen... fick inget som helst resultat. Men som sagt, var av ett skräpbilligt märke.

AciDBL00D
2003-06-28, 17:32
Det är ju inte lätt att veta om man får resultat. Man vet ju inte hur man sett ut om den burken inte hade gått ner. Så svårt att utvärdera

Bamse
2003-06-28, 17:46
Jag tappade fyra kilo på åtta veckors diet i våras. Vet ju emellertid inte hur mkt jag hade tappat om jag INTE använt CLA. Kanske 4,5 kg! :D

GhostFace
2003-06-28, 18:52
Will Brink har skrivit detta;

An update from Will Brink:

1. CLA studies:

Here are two recent studies that come to almost opposite
conclusions regarding CLA.

One finds CLA actually increases indicators of oxidative
stress and insulin resistance, while the second study found
CLA reduced abdominal fat in men with metabolic syndrome.
More interesting, they were done by the same group!

The take home appears to be, that CLA has isomer specific
effects. That is, for example, the t10c12 CLA-isomer may
increase oxidative stress while the CLA of mixed isomers
didn't appear to have this negative effects.

The reality is, CLA needs further research to really hash
out which isomers do which, in what amounts, etc, etc. Some
isomers have been found to have anti cancer and immune
modulating properties, at least in animals.

Stay tuned...
__________

Circulation. 2002 Oct 8;106(15):1925-9.

Supplementation with conjugated linoleic acid causes
isomer-dependent oxidative stress and elevated C-reactive
protein: a potential link to fatty acid-induced insulin
resistance.

Riserus U, Basu S, Jovinge S, Fredrikson GN, Arnlov J,
Vessby B.

Department of Public Health and Caring Sciences/Geriatrics,
Uppsala University, Uppsala, Sweden.
ulf.riserus@pubcare.uu.se

BACKGROUND: Conjugated linoleic acids (CLAs), a group of
fatty acids shown to have beneficial effects in animals, are
also used as weight loss supplements. Recently, we reported
that the t10c12 CLA-isomer caused insulin resistance in
abdominally obese men via unknown mechanisms.

The aim of the present study was to examine whether CLA has
isomer-specific effects on oxidative stress or inflammatory
biomarkers and to investigate the relationship between these
factors and induced insulin resistance.

METHODS AND RESULTS: In a double-blind placebo-controlled
trial, 60 men with metabolic syndrome were randomized to one
of 3 groups receiving t10c12 CLA, a CLA mixture, or placebo
for 12 weeks. Insulin sensitivity (euglycemic clamp), serum
lipids, in vivo lipid peroxidation (determined as urinary
8-iso-PGF(2alpha) [F2-isoprostanes]), 15-ketodihydro
PGF(2alpha), plasma vitamin E, plasma C-reactive protein,
tumor necrosis factor-alpha, and interleukin-6 were assessed
before and after treatment.

Supplementation with t10c12 CLA markedly increased
8-iso-PGF(2alpha) (578%) and C-reactive protein (110%)
compared with placebo (P<0.0001 and P<0.01, respectively)
and independent of changes in hyperglycemia or dyslipidemia.

The increases in 8-iso-PGF(2alpha), but not in C-reactive
protein, were significantly and independently related to
aggravated insulin resistance. Oxidative stress was related
to increased vitamin E levels, suggesting a compensatory
mechanism.

CONCLUSIONS: t10c12 CLA supplementation increases oxidative
stress and inflammatory biomarkers in obese men. The
oxidative stress seems closely related to induced insulin
resistance, suggesting a link between the fatty acid-induced
lipid peroxidation seen in the present study and insulin
resistance. These unfavorable effects of t10c12 CLA might be
of clinical importance with regard to cardiovascular
disease, in consideration of the widespread use of dietary
supplements containing this fatty acid.

Int J Obes Relat Metab Disord. 2001 Aug;25(8):1129-35.
__________

Conjugated linoleic acid (CLA) reduced abdominal adipose
tissue in obese middle-aged men with signs of the metabolic
syndrome: a randomised controlled trial.

Riserus U, Berglund L, Vessby B.

Clinical Nutrition Research Unit, Department of Public
Health and Caring Sciences/Geriatrics, Faculty of Medicine,
Uppsala University, Uppsala, Sweden.
ulf.riserus@geriatrik.uu.se

BACKGROUND: Abdominal obesity is strongly related to
metabolic disorders. Recent research suggests that dietary
conjugated linoleic acid (CLA) reduces body fat and may
improve metabolic variables in animals. The metabolic
effects of CLA in abdominally obese humans have not yet been
tested.

OBJECTIVE: To investigate the short-term effect of CLA on
abdominal fat and cardiovascular risk factors in middle-aged
men with metabolic disorders.

METHODS: Twenty-five abdominally obese men (waist-to-hip
ratio (WHR), 1.05+/-0.05; body mass index (BMI), 32+/-2.7
kg/m(2) (mean+/-s.d.)) who were between 39 and 64-y-old
participated in a double-blind randomised controlled trial
for 4 weeks. Fourteen men received 4.2 g CLA/day and 10 men
received a placebo. The main endpoints were differences
between the two groups in sagittal abdominal diameter (SAD),
serum cholesterol, low-density lipoprotein, high-density
lipoprotein, triglycerides, free fatty acids, glucose and
insulin.

RESULTS: At baseline, there were no significant differences
between groups in anthropometric or metabolic variables.
After 4 weeks there was a significant decrease in SAD (cm)
in the CLA group compared to placebo (P=0.04, 95% CI; -1.12,
-0.02). Other measurements of anthropometry or metabolism
showed no significant differences between the groups.

CONCLUSIONS: These results indicate that CLA supplementation
for 4 weeks in obese men with the metabolic syndrome may
decrease abdominal fat, without concomitant effects on
overall obesity or other cardiovascular risk factors.
Because of the limited sample size, the effects of CLA in
abdominal obesity need to be further investigated in larger
trials with longer duration.

Linnet
2003-06-28, 21:48
tack för infon!

GhostFace
2003-06-28, 22:42
Det var så lite så.

:thumbup:

Kimo
2003-06-30, 09:46
Jag köpte extra E-vitamintillskott och ökade på intaget av Omega-3 (krossade linfrön, fet fisk) för att undvika CLAs negativa effekter. Men vad jag har hört så försämrar CLA immunförsvaret också och mycket riktigt blev jag förkyld efter två veckors använding (nu i sommar!), så jag har tagit ett uppehåll för att bli ordentligt frisk. Har du några infektioner i kroppen så ska du också se upp, CLA försämrar återhämtningen då.