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Visa fullständig version : Spekulerad(?) funktion hos fettceller


Sniggel
2008-01-05, 22:57
Taget av Lyle Mcdonald från bodyrecomposition-forumen



"Ok, finally stickying this stupid post with some very minor modifications.

It's something I've mentioned over the years, an assertion that my exercise physiology professor had made wrt: fat loss.

Note that under normal conditions, fat cells contain ~90% triglycerides and ~10% other stuff where other stuff includes some water, the cellular machinery that makes all the stuff that fat cells make and a couple of other things that I'm forgetting right now. Basically, fat cells do not normally contain much water.

He told us that, after triglycerides were removed from the cell, that the fat cells refilled with water in the short-term, eventually the body dropped that water and the fat loss 'became evident' (a goofy way for me to try to describe when the fat loss actually shows up on calipers, one of those dumb Tanita scales, or visually).

If nothing else, this gives a plausible mechanism for the non-linear fat loss that is so often seen. Folks will do everything right for weeks with no results. then overnight, something happens and the scale drops a bunch. Many diet newsgroups and forums refer to this as a 'whoosh' which often follows a stall.

A couple of empirical data points in support of this: people who use tanita scales have often reported that it will tell them that their BF has gone up right before a 'whoosh' occurs and a big drop. This suggests something goofy is going on with water balance.

Another is that fat often gets squishy (suggesting a change in what's in there) prior to a drop in skinfolds/ improvement in appearance.

I looked for research on the topic for a decade to no success. I made up my own plausible mechanism having to do with glycerol levels in the fat cell (glycerol is hydrophilic); if fatty acids were being lost at a greater proportion than glycerol, this mght explain how water is attracted into the fat cell. Except that, usually, glycerol and fatty acid are released in about the proportion you'd expect (3:1 FFA:glycerol).

edit: For what very little it's worth, Colgan mentions something similar in OPtimum Sports Nutrition, something about the body 'tracking' glycerol to keep track of fat stores. It's possible that the research on this is just pre-medline. Or he and my teacher just pulled it out of the old ass.

A couple of years back, a paper came out showing an increase in water content of visceral fat with dieting. First semi-direct data I've seen. I don't recall the mechanism being mentioned but I may not have ever read the full paper.

I keep meaning to look into what happens to water balance hormones with dieting, but my laziness is just truly profound.

Edit: Of course, if I suppose if I ever got off my ass and figured out what was causing it, I could try to figure out how to fix it. But, see: profound laziness.... It's probably just a matter of drinking a shitton of water so that your body will quit being weird and holding onto what's in the system.

As a weird addendum: many folks have noticed that a refeed can often trigger a 'whoosh'. Is this somehow affecting water balance (this would make sense given the relationships of carbs and water, carbs tend to pull water into the muscle cells)? Is it that the increase in leptin that accompanies refeeds does something nifty? I have no answers but it's something some have noticed/mentioned, including myself. You'll have someone who dieted hard for a week or two and nothing appears to be happening. Then they'll go 'fuck it' and have a big cheat/meal or short refeed. And wake up 4 lbs lighter with a visual difference."



Någon som har bra koll på hur fettcellerna fungerar och om det kan vara möjligt att "något annat" tar triglyceriders plats under långvarig negativ fettbalans varpå "detta något" plötsligt försvinner ur systemet?

Koloftw
2008-01-05, 23:49
Någon som har bra koll på hur fettcellerna fungerar och om det kan vara möjligt att "något annat" tar triglyceriders plats under långvarig negativ fettbalans varpå "detta något" plötsligt försvinner ur systemet?

Lyle har bra koll, du hittar knappast många här (om någon?) som kan mer än Lyle. Har även sett Grandmaster skriva om det, t.ex:


Det är inte ovanligt att en del stagnerar i veckor, för att över en natt förlora 2-3 kg. En teori om detta är att när fettcellerna töms, ersätts de förlorade triglyceriderna med lika andelar vatten. Detta ger på vågen intrycket att ingenting händer. Du kan i vissa fall känna hur fettmassans konsistens tycks ändras under diet, om du rullar/trycker den mellan fingrarna. Är det hårt utgörs det av större delen fett, är det mjukt med små hårda bollar i, kan det vara ett tecken på att du håller vatten i fettcellerna. När och hur detta släpper kan man spekulera om. Ibland beter sig kroppen inte riktigt rationellt. Vissa triggar igång det genom att överäta en dag, andra genom att helt byta livsmedel en dag. Jag skulle föreslå det senare alternativet. Byt livsmedel för några dagar om se vad som händer. Håll samma kalorimängd som du äter nu. Ersätt exempelvis tonfisken med minikeso, äggen med kött etc.

Det är kanske det som är med ätardagar för en del, de känner sig mycket hårdare efter, fast i själva verket är det veckans fettförlust som visar sig? (Jag bara spekulerar).

Sniggel
2008-01-06, 01:15
Jo jag vet att Lyle är väldigt kunnig inom detta området. Fenomenet stämmer ju överens med vad många upplever under diet, inklusive mig själv. Men det skulle vara kul om det fanns några vetenskapliga bevis för det och varför det isåfall beter sig som det gör.

bollio
2008-01-06, 14:13
The body works in mysterious ways.

Jag gillar hur Lyle använder "stuff".